The chick embryo chorioallantoic membrane (CAM). A multifaceted experimental model

被引：238
作者：
Ribatti, Domenico [1 ,2 ]
机构：
[1] Univ Bari, Sch Med, Dept Basic Med Sci Neurosci & Sensory Organs, Policlin Piazza G Cesare 11, I-70124 Bari, Italy
[2] Natl Canc Inst Giovanni Paolo II, Bari, Italy
来源：
MECHANISMS OF DEVELOPMENT | 2016年 / 141卷
关键词：
Angiogenesis; Anti-angiogenesis; Tissue grafts; Tumor growth; Wound healing; FIBROBLAST-GROWTH-FACTOR; MATRIX IN-VIVO; TISSUE-SPECIFICITY; MELANOMA-CELLS; INTRAVITAL VIDEOMICROSCOPY; VIRAL NANOPARTICLES; HUMAN TUMORS; ANGIOGENESIS; SYSTEM; MICROCIRCULATION;
D O I：
10.1016/j.mod.2016.05.003
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
During avian development the mesodermal layers of the allantois and chorion fuse to form the chorioallantoic membrane (CAM). This structure rapidly expands generating a rich vascular network that provides an interface for gas and waste exchange. The CAM allows to study tissue grafts, tumor growth and metastasis, wound healing, drugs delivery and toxicologic analysis, and angiogenic and anti-angiogenic molecules. The CAM is relatively simple, quick, and low-cost model that allows screening of a large number of pharmacological samples in a short time; does not require administrative procedures for obtaining ethics committee approval for animal experimentation. Moreover, being naturally immunodeficient, the chick embryo may receive transplantations from different tissues and species, without immune responses. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：70 / 77
页数：8
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