The Relationship of Collagen Structural and Compositional Heterogeneity to Tissue Mechanical Properties: A Chemical Perspective

被引：40

作者：

Chen, Junjie ^{[1
]}

Ahn, Taeyong ^{[2
]}

Colon-Bernal, Isabel D. ^{[1
]}

Kim, Jinhee ^{[1
]}

Holl, Mark M. Banaszak ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Macromol Sci & Engn, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

来源：

ACS NANO | 2017年 / 11卷 / 11期

基金：

美国国家科学基金会;

关键词：

ATOMIC-FORCE MICROSCOPY; I COLLAGEN; OSTEOGENESIS IMPERFECTA; ESTROGEN DEPLETION; NANOSCALE MORPHOLOGY; DISCRETE PLASTICITY; FIBRIL DIAMETER; BONE; TENDON; DAMAGE;

D O I：

10.1021/acsnano.7b06826

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Collagen is the primary protein component in mammalian connective tissues. Over the last 20 years, evidence has mounted that collagen matrices exhibit substantial heterogeneity in their hierarchical structures and that this heterogeneity plays important roles in both structure and function. Herein, an overview of studies addressing the nanoscale compositional and structural heterogeneity is provided and connected to work exploring the mechanical implications for a number of tissues.

引用

收藏

页码：10665 / 10671

页数：7

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