Isolation of Mycobacterium tuberculosis Strains with a Silent Mutation in rpoB Leading to Potential Misassignment of Resistance Category

被引：52

作者：

Alonso, Maria ^{[1
]}

Jose Palacios, Juan ^{[2
]}

Herranz, Marta ^{[1
]}

Penedo, Ana ^{[2
]}

Menendez, Angela ^{[2
]}

Bouza, Emilio ^{[1
]}

Garcia de Viedma, Dario ^{[1
]}

机构：

[1] Hosp Gregorio Maranon, Serv Microbiol & Enfermedades Infecciosas, Madrid, Spain

[2] Hosp Univ Cent Asturias, Unidad Referencia Reg Micobacterias, Oviedo, Spain

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2011年 / 49卷 / 07期

关键词：

FRAGMENT-LENGTH-POLYMORPHISM; NEW-YORK; EVOLUTION; DIVERSITY;

D O I：

10.1128/JCM.00659-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Our study provides an alert regarding the transmission of rifampin-susceptible strains of Mycobacterium tuberculosis with a silent substitution in codon 514 of rpoB. Among 1,450 cases, we identified 12 isolates sharing this mutation and related restriction fragment length polymorphism (RFLP) types. The mutation impaired hybridization with the wild-type probes in three independent commercial assays, which could lead to misassignment of resistance.

引用

页码：2688 / 2690

页数：3

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