Cascade Reaction of Isatins with Heterocyclic Ketene Aminals: Synthesis of Imidazopyrroloquinoline Derivatives

被引：120

作者：

Yu, Fuchao ^{[1
]}

Yan, Shengjiao ^{[1
]}

Hu, Ling ^{[1
]}

Wang, Yongchao ^{[1
]}

Lin, Jun ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resources, Kunming 650091, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 18期

关键词：

ADENOSINE RECEPTOR ANTAGONISTS; IN-VITRO; ANTIPROLIFERATIVE EVALUATION; QUINOLINE SYNTHESIS; ANTIBACTERIAL; AGENTS; CONSTRUCTION; PYRIDINE; NITROGEN; TAS-103;

D O I：

10.1021/ol201783d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise and efficient route for the synthesis of highly substituted imidazopyrroloquinoline derivatives by simply refluxing a reaction mixture of different types of isatins and heterocyclic ketene aminals (HKAs) by acetic acid was developed. This method is suitable for combinatorial and parallel syntheses in drug discovery; consequently, a library of highly substituted imidazopyrroloquinoline derivatives was rapidly constructed using the present protocol.

引用

页码：4782 / 4785

页数：4

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