The effect of environmental chemicals on the tumor microenvironment

被引：104

作者：

Casey, Stephanie C. ^{[1
,2
]}

Vaccari, Monica ^{[3
]}

Al-Mulla, Fahd ^{[4
]}

Al-Temaimi, Rabeah ^{[4
]}

Amedei, Amedeo ^{[5
]}

Barcellos-Hoff, Mary Helen ^{[6
]}

Brown, Dustin G. ^{[7
]}

Chapellier, Marion ^{[8
]}

Christopher, Joseph ^{[9
]}

Curran, Colleen ^{[10
]}

Forte, Stefano ^{[11
]}

Hamid, Roslida A. ^{[12
]}

Heneberg, Petr ^{[13
]}

Koch, Daniel C. ^{[1
]}

Krishnakumar, P. K. ^{[14
]}

Laconi, Ezio ^{[15
]}

Maguer-Satta, Veronique ^{[8
]}

Marongiu, Fabio ^{[15
]}

Memeo, Lorenzo ^{[16
]}

Mondello, Chiara ^{[17
]}

Raju, Jayadev ^{[18
]}

Roman, Jesse ^{[19
]}

Roy, Rabindra ^{[20
]}

Ryan, Elizabeth P. ^{[7
]}

Ryeom, Sandra ^{[21
]}

Salem, Hosni K. ^{[22
]}

Scovassi, A. Ivana ^{[17
]}

Singh, Neetu ^{[23
]}

Soucek, Laura ^{[24
,25
]}

Vermeulen, Louis ^{[26
]}

Whitfield, Jonathan R. ^{[24
,25
]}

Woodrick, Jordan ^{[20
]}

Colacci, Annamaria ^{[3
]}

Bisson, William H. ^{[27
]}

Felsher, Dean W. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Med, Div Oncol, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Pathol, Div Oncol, Stanford, CA 94305 USA

[3] Environm Protect & Hlth Prevent Agcy, Ctr Environm Carcinogenesis & Risk Assessment, I-40126 Bologna, Italy

[4] Kuwait Univ, Dept Pathol, Safat 13110, Kuwait

[5] Univ Firenze, Dept Expt & Clin Med, I-50134 Florence, Italy

[6] NYU, Sch Med, Dept Radiat Oncol, New York, NY 10016 USA

[7] Colorado State Univ, Colorado Sch Publ Hlth, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA

[8] Univ Lyon, Ctr Rech Cancerol Lyon, U1052, UMR5286, F-69007 Lyon, France

[9] Univ Cambridge, Cambridge Inst, Canc Res UK, Cambridge CB2 0RE, England

[10] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53705 USA

[11] Mediterranean Inst Oncol, I-95029 Viagrande, Italy

[12] Univ Putra Malaysia, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia

[13] Charles Univ Prague, Fac Med 3, Prague 10000 10, Czech Republic

[14] King Fahd Univ Petr & Minerals, Res Inst, Ctr Environm & Water, Dhahran 31261, Saudi Arabia

[15] Univ Cagliari, Dept Sci & Biomed Technol, I-09124 Cagliari, Italy

[16] Mediterranean Inst Oncol, Pathol Unit, I-95029 Viagrande, Italy

[17] CNR, Inst Mol Genet, I-27100 Pavia, Italy

[18] Hlth Canada, Regulatory Toxicol Res Div, Bur Chem Safety, Food Directorate,Hlth Prod & Food Branch, Ottawa, ON K1A0K9, Canada

[19] Univ Louisville, Dept Med, Louisville, KY 40202 USA

[20] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Mol Oncol Program, Washington, DC 20057 USA

[21] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[22] Cairo Univ, Kasr Al Airiy Sch Med, Dept Urol, Cairo 11562, Egypt

[23] King Georges Med Univ, Ctr Adv Res, Lucknow 226003, Uttar Pradesh, India

[24] Vall dHebron Inst Oncol VHIO, Barcelona 08035, Spain

[25] ICREA, Barcelona 08035, Spain

[26] Univ Amsterdam, Acad Med Ctr, CEMM, NL-1105 AZ Amsterdam, Netherlands

[27] Oregon State Univ, Environm Hlth Sci Ctr, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA

来源：

CARCINOGENESIS | 2015年 / 36卷

关键词：

ACTIVATED PROTEIN-KINASE; NATURAL-KILLER-CELLS; ENDOCRINE-DISRUPTING CHEMICALS; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; TOBACCO-SPECIFIC CARCINOGEN; OXYGEN SPECIES ROS; BISPHENOL-A; OXIDATIVE STRESS;

D O I：

10.1093/carcin/bgv035

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through effects on the tumor microenvironment. In turn, the tumor microenvironment consists of a complex interaction among blood vessels that feed the tumor, the extracellular matrix that provides structural and biochemical support, signaling molecules that send messages and soluble factors such as cytokines. The tumor microenvironment also consists of many host cellular effectors including multipotent stromal cells/mesenchymal stem cells, fibroblasts, endothelial cell precursors, antigen-presenting cells, lymphocytes and innate immune cells. Carcinogens can influence the tumor microenvironment through effects on epithelial cells, the most common origin of cancer, as well as on stromal cells, extracellular matrix components and immune cells. Here, we review how environmental exposures can perturb the tumor microenvironment. We suggest a role for disrupting chemicals such as nickel chloride, Bisphenol A, butyltins, methylmercury and paraquat as well as more traditional carcinogens, such as radiation, and pharmaceuticals, such as diabetes medications, in the disruption of the tumor microenvironment. Further studies interrogating the role of chemicals and their mixtures in dose-dependent effects on the tumor microenvironment could have important general mechanistic implications for the etiology and prevention of tumorigenesis.In this review, we discuss how environmental exposures can perturb the tumor microenvironment, a complex network comprised of fibroblasts, epithelial cells, stroma, extracellular matrix and immune cells, and contribute to multiple stages of tumor growth.

引用

页码：S160 / S183

页数：24

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