Epigenetic Memories in Hematopoietic Stem and Progenitor Cells

被引:12
作者
Aoyama, Kazumasa [1 ]
Itokawa, Naoki [1 ]
Oshima, Motohiko [1 ]
Iwama, Atsushi [1 ]
机构
[1] Univ Tokyo, Ctr Stem Cell Biol & Regenerat Med, Inst Med Sci, Div Stem Cell & Mol Med,Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan
基金
日本学术振兴会;
关键词
next-generation sequencing; epigenetic memory; epigenome; chromatin accessibility; hematopoietic stem cells; hematopoietic progenitor cells; innate immune cells; SINGLE-CELL; CHROMATIN ACCESSIBILITY; INNATE IMMUNITY; RNA-SEQ; MYCOBACTERIUM-TUBERCULOSIS; REGULATORY ELEMENTS; IFN-GAMMA; P-TEFB; HI-C; GENOME;
D O I
10.3390/cells11142187
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The recent development of next-generation sequencing (NGS) technologies has contributed to research into various biological processes. These novel NGS technologies have revealed the involvement of epigenetic memories in trained immunity, which are responses to transient stimulation and result in better responses to secondary challenges. Not only innate system cells, such as macrophages, monocytes, and natural killer cells, but also bone marrow hematopoietic stem cells (HSCs) have been found to gain memories upon transient stimulation, leading to the enhancement of responses to secondary challenges. Various stimuli, including microbial infection, can induce the epigenetic reprogramming of innate immune cells and HSCs, which can result in an augmented response to secondary stimulation. In this review, we introduce novel NGS technologies and their application to unraveling epigenetic memories that are key in trained immunity and summarize the recent findings in trained immunity. We also discuss our most recent finding regarding epigenetic memory in aged HSCs, which may be associated with the exposure of HSCs to aging-related stresses.
引用
收藏
页数:14
相关论文
共 50 条
[41]   Mycobacterium tuberculosis infection drives differential responses in the bone marrow hematopoietic stem and progenitor cells [J].
Bobba, Suhas ;
Howard, Nicole C. ;
Das, Shibali ;
Ahmed, Mushtaq ;
Khan, Nargis ;
Marchante, Ignacio ;
Barreiro, Luis B. ;
Sanz, Joaquin ;
Divangahi, Maziar ;
Khader, Shabaana A. .
INFECTION AND IMMUNITY, 2023,
[42]   CD97 is differentially expressed on murine hematopoietic stem- and progenitor-cells [J].
van Pel, Melissa ;
Hagoort, Henny ;
Hamann, Joerg ;
Fibbe, Willem E. .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 (08) :1137-1144
[43]   Simultaneous Measurement of Human Hematopoietic Stem and Progenitor Cells in Blood Using Multicolor Flow Cytometry [J].
Cimato, Thomas R. ;
Furlage, Rosemary L. ;
Conway, Alexis ;
Wallace, Paul K. .
CYTOMETRY PART B-CLINICAL CYTOMETRY, 2016, 90 (05) :415-423
[44]   Hematopoietic Stem Cells and Their Niche in Bone Marrow [J].
Kwon, Munju ;
Kim, Byoung Soo ;
Yoon, Sik ;
Oh, Sae-Ock ;
Lee, Dongjun .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (13)
[45]   New relationships of human hematopoietic lineages facilitate detection of multipotent hematopoietic stem and progenitor cells [J].
Goergens, Andre ;
Radtke, Stefan ;
Horn, Peter A. ;
Giebel, Bernd .
CELL CYCLE, 2013, 12 (22) :3478-3482
[46]   Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells [J].
Morales-Mantilla, Daniel E. ;
Kain, Bailee ;
Le, Duy ;
Flores, Anthony R. ;
Paust, Silke ;
King, Katherine Y. .
ELIFE, 2022, 11
[47]   Enrichment of Human Hematopoietic Stem/Progenitor Cells Facilitates Transduction for Stem Cell Gene Therapy [J].
Baldwin, Kismet ;
Urbinati, Fabrizia ;
Romero, Zulema ;
Campo-Fernandez, Beatriz ;
Kaufman, Michael L. ;
Cooper, Aaron R. ;
Masiuk, Katelyn ;
Hollis, Roger P. ;
Kohn, Donald B. .
STEM CELLS, 2015, 33 (05) :1532-1542
[48]   3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche [J].
Leisten, Isabelle ;
Kramann, Rafael ;
Ferreiraa, Monica S. Ventura ;
Bovi, Manfred ;
Neuss, Sabine ;
Ziegler, Patrick ;
Wagner, Wolfgang ;
Knuechel, Ruth ;
Schneider, Rebekka K. .
BIOMATERIALS, 2012, 33 (06) :1736-1747
[49]   High Canonical Wnt/β-Catenin Activity Sensitizes Murine Hematopoietic Stem and Progenitor Cells to DNA Damage [J].
Yiting Wang ;
Hui Cui ;
Si Tao ;
Ting Zeng ;
Jianying Wu ;
Zhendong Tao ;
Liu Zhang ;
Bing Zou ;
Zhiyang Chen ;
George B. Garside ;
Duozhuang Tang .
Stem Cell Reviews and Reports, 2020, 16 :212-221
[50]   Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling—an update [J].
Mariusz Z. Ratajczak ;
Mateusz Adamiak ;
Kamila Bujko ;
Arjun Thapa ;
Valentina Pensato ;
Magda Kucia ;
Janina Ratajczak ;
Henning Ulrich .
Purinergic Signalling, 2020, 16 :153-166