Slowly progressive systemic mastocytosis with high mast-cell burden and no evidence of a non-mast-cell hematologic disorder: an example of a smoldering case?

被引：26

作者：

Akin, C ^{[1
]}

Scott, LM ^{[1
]}

Metcalfe, DD ^{[1
]}

机构：

[1] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA

来源：

LEUKEMIA RESEARCH | 2001年 / 25卷 / 07期

关键词：

bone marrow; classification; mastocytosis; urticaria pigmentosa;

D O I：

10.1016/S0145-2126(01)00023-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 43-year-old man with extensive systemic mastocytosis with poor prognostic indicators but no overt hematologic abnormality is described. This patient's clinical presentation and course are consistent with the newly proposed 'smoldering mastocytosis' category. Long-term follow-up of patients is needed to determine whether they may be at higher risk for progression into more aggressive categories. Published by Elsevier Science Ltd.

引用

收藏

页码：635 / 638

页数：4

相关论文

共 9 条

[1] Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology [J].

Akin, C ;

Schwartz, LB ;

Kitoh, T ;

Obayashi, H ;

Worobec, AS ;

Scott, LM ;

Metcalfe, DD .

BLOOD, 2000, 96 (04) :1267-1273

[2]

AKIN C, 2000, ALLERGIC SKIN DIS MU, P337

[3] HEMATOLOGIC MANIFESTATIONS OF SYSTEMIC MAST-CELL DISEASE - A PROSPECTIVE-STUDY OF LABORATORY AND MORPHOLOGICAL FEATURES AND THEIR RELATION TO PROGNOSIS [J].

LAWRENCE, JB ;

FRIEDMAN, BS ;

TRAVIS, WD ;

CHINCHILLI, VM ;

METCALFE, DD ;

GRALNICK, HR .

AMERICAN JOURNAL OF MEDICINE, 1991, 91 (06) :612-624

[4] IDENTIFICATION OF A POINT MUTATION IN THE CATALYTIC DOMAIN OF THE PROTOONCOGENE C-KIT IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF PATIENTS WHO HAVE MASTOCYTOSIS WITH AN ASSOCIATED HEMATOLOGIC DISORDER [J].

NAGATA, H ;

WOROBEC, AS ;

OH, CK ;

CHOWDHURY, BA ;

TANNENBAUM, S ;

SUZUKI, Y ;

METCALFE, DD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) :10560-10564

[5] The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis [J].

Schwartz, LB ;

Sakai, K ;

Bradford, TR ;

Ren, SL ;

Zweiman, B ;

Worobec, AS ;

Metcalfe, DD .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (06) :2702-2710

[6]

TRAVIS WD, 1990, MEDICINE, V69, P34

[7] Diagnostic criteria and classification of mastocytosis:: a consensus proposal [J].

Valent, P ;

Horny, HP ;

Escribano, L ;

Longley, BJ ;

Li, CY ;

Schwartz, LB ;

Marone, G ;

Nuñez, R ;

Akin, C ;

Sotlar, K ;

Sperr, WR ;

Wolff, K ;

Brunning, RD ;

Parwaresch, RM ;

Austen, KF ;

Lennert, K ;

Metcalfe, DD ;

Vardiman, JW ;

Bennett, JM .

LEUKEMIA RESEARCH, 2001, 25 (07) :603-625

[8]

Worobec AS, 1998, CANCER, V83, P2120, DOI 10.1002/(SICI)1097-0142(19981115)83:10<2120::AID-CNCR10>3.0.CO

[9]

2-C