Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane

被引：85

作者：

Lucken-Ardjomande, S ^{[1
]}

Martinou, JC ^{[1
]}

机构：

[1] Univ Geneva, Dept Cell Biol, CH-1211 Geneva, Switzerland

来源：

COMPTES RENDUS BIOLOGIES | 2005年 / 328卷 / 07期

关键词：

apoptosis; mitochondria; permeabilization; Bax; Bcl-2; lipids; cardiolipin;

D O I：

10.1016/j.crvi.2005.05.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In many apoptotic responses, pro-apoptotic members of the Bcl-2 family trigger the permeabilization of the outer mitochondrial membrane, thereby allowing the release of mitochondrial apoptogenic factors that contribute to caspase activation in the cytosol. The mechanisms that lead to the activation of pro-apoptotic Bcl-2 family members and to the permeabilization of the outer mitochondrial membrane are not yet completely understood. Here, we attempt to summarize our current view of the mechanisms that lead to these events, regarding both additional proteins that were recently suggested to be involved, and the roles of lipids. (c) 2005 Academie des sciences. Published by Elsevier SAS. All rights reserved.

引用

页码：616 / 631

页数：16

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