Polymeric Nanoparticle Based Diagnosis and Nanomedicine for Treatment and Development of Vaccines for Cerebral Malaria: A Review on Recent Advancement

被引:16
作者
Patra, Sukanya [1 ]
Singh, Monika [1 ]
Wasnik, Kirti [1 ]
Pareek, Divya [1 ]
Gupta, Prem Shankar [1 ]
Mukherjee, Sudip [2 ]
Paik, Pradip [1 ]
机构
[1] Indian Inst Technol BHU, Sch Biomed Engn, Varanasi 221005, Uttar Pradesh, India
[2] Rice Univ, Dept Bioengn, Houston, TX 77030 USA
关键词
polymeric nanomedicine; cerebral malaria; diagnostic tool; therapeutics; vaccination; clinical trials; TARGETING GENE DELIVERY; HUMANIZED MOUSE MODELS; HYDROGEL MATRIX PATCH; IN-VITRO RELEASE; RED-BLOOD-CELLS; PLASMODIUM-FALCIPARUM; DRUG-DELIVERY; COMBINATION THERAPY; PLASMID DNA; ANTIMALARIAL ACTIVITY;
D O I
10.1021/acsabm.1c00635
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Cerebral malaria occurs due to Plasmodium falciparum infection, which causes 228 million infections and 450,000 deaths worldwide every year. African people are mostly affected with nearly 91% cases, of which 86% are pregnant women and infants. India and Brazil are the other two countries severely suffering from malaria endemicity. Commonly used drugs have severe side effects, and unfortunately no suitable vaccine is available in the market today. In this line, this review is focused on polymeric nanomaterials and nanocapsules that can be used for the development of effective diagnostic strategies, nanomedicines, and vaccines in the management of cerebral malaria. Further, this review will help scientists and medical professionals by updating the status on the development stages of polymeric nanoparticle based diagnostics, nanomedicines, and vaccines and strategies to eradicate cerebral malaria. In addition to this, the predominant focus of this review is antimalarial agents based on polymer nanomedicines that are currently in the preclinical and clinical trial stages, and potential developments are suggested as well. This review further will have an important social and commercial impact worldwide for the development of polymeric nanomedicines and strategies for the treatment of cerebral malaria.
引用
收藏
页码:7342 / 7365
页数:24
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