Control of growth by the somatropic axis: Growth hormone and the insulin-like growth factors have related and independent roles

被引：282

作者：

Butler, AA ^{[1
]}

Le Roith, D

机构：

[1] Oregon Hlth & Sci Univ, Vollum Inst Adv Biomed Res, Portland, OR 97201 USA

[2] NIDDK, Clin Endocrinol Branch, NIH, Bethesda, MD 20892 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 2001年 / 63卷

关键词：

conditional knockouts; somatomedin hypothesis; cell proliferation;

D O I：

10.1146/annurev.physiol.63.1.141

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The traditionally accepted theory has been that most of the biological effects of growth hormone (GH) are mediated by circulating (endocrine) insulin-like growth factor-I (IGF-I). This dogma was modified when it was discovered that most tissues express IGF-I that can act via an autocrine/paracrine fashion. In addition, both GH and IGF-I had independent effects on various target tissues. Using tissue-specific gene deletion of IGF-I in the liver, it has been shown that circulating IGF-I is predominantly liver-derived but is not essential for normal postnatal growth. Therefore, it is proposed that non-hepatic tissue-derived IGF-I may be sufficient for growth and development. Thus the original somatomedin hypothesis has undergone further modifications.

引用

页码：141 / 164

页数：24

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