Therapeutic drug monitoring (TDM) of gentamicin in critically ill neonates

被引:0
作者
Martinkova, J. [1 ]
Pokorna, P. [1 ]
Zahora, J. [1 ]
Selke-Krulichova, I. [1 ]
机构
[1] Charles Univ Prague, Fac Med, Dept Pharmacol, Hradec Kralove, Czech Republic
来源
PROCEEDINGS OF THE 8TH CONGRESS OF THE EUROPEAN ASSOCIATION FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS | 2007年
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中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
First dose plasma concentrations (Cpl) of GE in neonates during the first week of life seem to be predictive of steady state Cpl in those without co-variates significantly modifying pharmacokinetics (PK) of GE such as water retention (systemic capillary leak syndrome) and furosemide given as a bolus dose > 1mg/kg BW or continuous i. v. infusion.
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收藏
页码:163 / +
页数:2
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