Pd-catalyzed dynamic kinetic enantioselective arylation of silylphosphines

被引：121
作者：
Chan, Vincent S. [1 ]
Bergman, Robert G. [1 ]
Toste, F. Dean [1 ]
机构：
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 49期
关键词：
D O I：
10.1021/ja076457r
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Palladium-catalyzed cross-couplings represent a powerful method for the formatioil of new bonds. A catalytic, enantioselective P-C bond-forming reaction proceeding via a Pd-mediated arylation of silylphosphines was developed for the synthesis of P-stereogenic phosphines. These useful and synthetically challenging phosphines can be made with a variety of functionalized aryl iodides; however, they proceed most enantioselectively with 2-iodo-N ,N -diisopropylbenzamides.
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页码：15122 / +
页数：3
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