A New Insight into the Synthesis and Biological Activities of Pyrazole based Derivatives

被引：13

作者：

Mor, Satbir ^{[1
]}

Khatri, Mohini ^{[1
]}

Punia, Ravinder ^{[1
]}

Nagoria, Savita ^{[2
]}

Sindhu, Suchita ^{[1
]}

机构：

[1] Guru Jambheshwar Univ Sci & Technol, Dept Chem, Hisar 125001, Haryana, India

[2] Govt Coll, Dept Chem, Hisar 125001, Haryana, India

来源：

MINI-REVIEWS IN ORGANIC CHEMISTRY | 2022年 / 19卷 / 06期

关键词：

Pyrazole; 1,3-dicarbonyl compounds; alpha; beta-unsaturated compounds; 1,3-dipolar cycloaddition; pharmacological activities; anticancer; anti-inflammatory; herbicidal; ONE-POT SYNTHESIS; ORALLY-ACTIVE PYRAZOLOQUINOLINES; FORMAL 4+1 ANNULATION; CATALYZED ONE-POT; REGIOSELECTIVE SYNTHESIS; HERBICIDAL ACTIVITY; ANTIBACTERIAL ACTIVITY; SUBSTITUTED PYRAZOLES; FACILE SYNTHESIS; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE;

D O I：

10.2174/1570193X19666220118111614

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review aims to collate literature work reported by researchers (from 1994 to 2021) to provide an overview of the available methodologies for the synthesis and diverse pharmacological activities exhibited by pyrazole based molecules. This review highlights recent reports on various routes of synthesis and potential biological evaluation studies viz. anticancer, AT (II) inhibitory, anti-inflammatory activities, HIV-1-RT inhibitory, antihypertensive, herbicidal, antitubercular, insecticidal, antiviral, antimicrobial, and COX-2 inhibitory activity, etc., of pyrazole derivatives and also presents recent efforts made on this heterocyclic moiety.

引用

页码：717 / 778

页数：62

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