Increased brain response to appetitive tastes in the insula and amygdala in obese compared with healthy weight children when sated

被引:60
作者
Boutelle, K. N. [1 ,2 ]
Wierenga, C. E. [1 ,3 ]
Bischoff-Grethe, A. [1 ]
Melrose, A. J. [1 ]
Grenesko-Stevens, E. [1 ]
Paulus, M. P. [1 ,3 ]
Kaye, W. H. [1 ]
机构
[1] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA
[3] Vet Affairs San Diego Healthcare Syst, Res Serv, San Diego, CA USA
关键词
CHILDHOOD OBESITY; STRUCTURAL MRI; FOOD-INTAKE; REWARD; ACTIVATION; DOPAMINE; CORTEX; STIMULATION; UNCERTAINTY; RELIABILITY;
D O I
10.1038/ijo.2014.206
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: There is evidence of altered neural taste response in female adolescents who are obese (OB), and in adolescents who are at risk for obesity. To further understand risk factors for the development of overeating and obesity, we investigated response to tastes of sucrose and water in 23 OB and healthy weight (HW) children. METHODS AND DESIGN: Thirteen HW and 10 OB 8-12-year-old children underwent functional magnetic resonance imaging while tasting sucrose and water. Additionally, children completed an eating in the absence of hunger paradigm and a sucrose-liking task. RESULTS: A region of interest analysis revealed an elevated BOLD response to taste (sucrose and water) within the bilateral insula and amygdala in OB children relative to HW children. Whole-brain analyses revealed a group by condition interaction within the paracingulate, medial frontal, middle frontal gyri and right amygdala: post hoc analyses suggested an increased response to sucrose for OB relative to HW children, whereas HW children responded more strongly to water relative to sucrose. In addition, OB children, relative to HW, tended to recruit the right putamen as well as medial and lateral frontal and temporal regions bilaterally. CONCLUSION: This study showed increased reactivity in the amygdala and insula in the OB compared with HW children, but no functional differentiation in the striatum, despite differences in the striatum previously seen in older samples. These findings support the concept of the association between increased neural processing of food reward in the development of obesity, and raise the possibility that emotional and interoceptive sensitivity could be an early vulnerability in obesity.
引用
收藏
页码:620 / 628
页数:9
相关论文
共 56 条
[1]   CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].
BENJAMINI, Y ;
HOCHBERG, Y .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300
[2]  
Berthoud HR, 2006, OBESITY, V14, P197
[3]   Childhood obesity and adult morbidities [J].
Biro, Frank M. ;
Wien, Michelle .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 91 (05) :1499S-1505S
[4]   Two Novel Treatments to Reduce Overeating in Overweight Children: A Randomized Controlled Trial [J].
Boutelle, Kerri N. ;
Zucker, Nancy L. ;
Peterson, Carol B. ;
Rydell, Sarah A. ;
Cafri, Guy ;
Harnack, Lisa .
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 2011, 79 (06) :759-771
[5]   Obese children show hyperactivation to food pictures in brain networks linked to motivation, reward and cognitive control [J].
Bruce, A. S. ;
Holsen, L. M. ;
Chambers, R. J. ;
Martin, L. E. ;
Brooks, W. M. ;
Zarcone, J. R. ;
Butler, M. G. ;
Savage, C. R. .
INTERNATIONAL JOURNAL OF OBESITY, 2010, 34 (10) :1494-1500
[6]  
Burger Kyle S, 2011, Curr Drug Abuse Rev, V4, P182
[7]   The feasibility of a common stereotactic space for children and adults in fMRI studies of development [J].
Burgund, ED ;
Kang, HC ;
Kelly, JE ;
Buckner, RL ;
Snyder, AZ ;
Petersen, SE ;
Schlaggar, BL .
NEUROIMAGE, 2002, 17 (01) :184-200
[8]   Neurodevelopment, impulsivity, and adolescent gambling [J].
Chambers R.A. ;
Potenza M.N. .
Journal of Gambling Studies, 2003, 19 (1) :53-84
[9]   AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages [J].
Cox, RW .
COMPUTERS AND BIOMEDICAL RESEARCH, 1996, 29 (03) :162-173
[10]   Neural activity in the human brain relating to uncertainty and arousal during anticipation [J].
Critchley, HD ;
Mathias, CJ ;
Dolan, RJ .
NEURON, 2001, 29 (02) :537-545