Role of Glucocorticoids in Breast Cancer

被引：0

作者：

Vaidya, Jayant S. ^{[1
]}

Baldassarre, Gustavo

Thorat, Mangesh A. ^{[3
]}

Massarut, Samuele ^{[2
]}

机构：

[1] UCL, Div Surg & Intervent Sci, Dept Surg Res, London N19 5LW, England

[2] Natl Canc Inst, Ctr Riferimento Oncol, Breast Surg Unit, Aviano, Italy

[3] Univ London, Barts & London Sch Med & Dent Queen Mary, Wolfson Inst Prevent Med, CRUK Ctr Epidemiol Math & Stat, London WC1E 7HU, England

来源：

CURRENT PHARMACEUTICAL DESIGN | 2010年 / 16卷 / 32期

关键词：

Glucocorticoids; steroids; breast cancer; review; circadian; paracrine; glucocorticoid receptor; treatment; TARGETED INTRAOPERATIVE RADIOTHERAPY; RADIATION-INDUCED APOPTOSIS; PRIMARY ENDOCRINE TREATMENT; STEROID-HORMONE RECEPTORS; CERVICAL-CARCINOMA CELLS; MAMMARY EPITHELIAL-CELLS; ONCOLOGY-GROUP TRIAL; FACTOR-KAPPA-B; ESTROGEN-RECEPTOR; MEDROXYPROGESTERONE ACETATE;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glucocorticoids play an essential role in embryonic development and tissue homeostasis and possess important anti-inflammatory and immunosuppressive properties. Due to their very wide spectrum of activity, glucocorticoids are one of the most commonly used drugs-used in the treatment of asthma, arthritis, autoimmune diseases and shock/SIRS. Glucocorticoids are a main component of treatment regimens in hematological malignancies due to their pro-apoptotic properties and are also used as co-treatment several other cancers and chemotherapy regimens including those in breast cancer treatment. In breast cancer, however, glucocorticoids may have diverse effects and could inhibit chemosensitivity. Additionally, glucocorticoids through their receptor may interact with ER in a feedback loop regulating each other's activities. The normal variation of glucocorticoid levels with time of the day, menstrual cycle or year could have a interesting chronobiological interaction with the well recorded variation in breast cancer proliferation and metastatic potential. Glucocorticoids could play a very complex role in breast cancer epidemiology, biology and treatment; this review aims to present a comprehensive discussion as well as speculate future directions for research.

引用

页码：3593 / 3600

页数：8

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