miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2

被引：166

作者：

Ma, Yihui

Yu, Shuangni

Zhao, Wugan

Lu, Zhaohui

Chen, Jie ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Pathol, Beijing 100730, Peoples R China

来源：

CANCER LETTERS | 2010年 / 298卷 / 02期

关键词：

miR-27a; Oncogene; Pancreatic adenocarcinoma; Spry2; TUMOR-SUPPRESSOR; KINASE PATHWAY; INHIBITOR; MICRORNA-21; EXPRESSION; PROTEIN; RAS; SPRY2; ADENOCARCINOMA; PROLIFERATION;

D O I：

10.1016/j.canlet.2010.06.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs are short regulatory RNAs A growing body of data implicates altered miRNA participate in the development of cancers and miR-27a is abnormally upregulated in several types of cancers identified as an oncogene Although overexpressed in pancreatic adenocarcinoma the oncogenic role of miR-27a has not yet been reported In this study we showed that inhibition of miR-27a suppressed the growth colony formation and migration of pancreatic cancer cells By using a reporter-screening assay we discovered that the 3'UTR of Sprouty2 (Spty2) carried a putative miR-27a binding site Furthermore the Spry2 protein which has a low expression level in pancreatic adenocarcinoma was upregulated by transfection with a miR-27a inhibitor The data reported here are the first to indicate that miR-27a plays an oncogenic role by targeting Spry2 and modulating the malignant biological behavior of pancreatic cancer cells This suggests the potential for miR-27a to be used as a target in the diagnosis and treatment of pancreatic adenocarcinoma (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：150 / 158

页数：9

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