Low serum levels of cathelicidin LL-37 in leprosy

被引：18

作者：

Matzner, Michael ^{[2
]}

Al Samie, Abdul Rahim ^{[3
]}

Winkler, Heide-Maria ^{[1
]}

Nemeth, Johannes ^{[1
]}

Grasnek, Andreas ^{[1
]}

Indra, Alexander ^{[4
]}

Bieglmayer, Christian ^{[5
,6
]}

Winkler, Stefan ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 1, Div Infect Dis & Trop Med, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Orthopaed Surg, A-1090 Vienna, Austria

[3] Minist Hlth & Populat, Natl Leprosy Eliminat Program, Taizi, Yemen

[4] Austrian Agcy Hlth & Food Safety AGES, A-1096 Vienna, Austria

[5] Med Univ Vienna, Inst Clin Med, A-1090 Vienna, Austria

[6] Med Univ Vienna, Chem Lab Diagnost, A-1090 Vienna, Austria

来源：

ACTA TROPICA | 2011年 / 117卷 / 01期

关键词：

Leprosy; M; leprae; Cathelicidin; Vitamin D3; MYCOBACTERIUM-TUBERCULOSIS; ANTIMICROBIAL PEPTIDES; DEFICIENCY; EXPRESSION; INFECTION; RESPONSES; DEFENSE; DISEASE; HCAP18; SKIN;

D O I：

10.1016/j.actatropica.2010.09.007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The antimicrobial peptide cathelicidin LL-37 possesses antituberculous activity, its association with other mycobacterial diseases, such as leprosy, is unknown. We studied serum cathelicidin and 25OH-vitamin D3 levels in 29 leprosy patients and 19 healthy individuals from Yemen. Cathelicidin levels were significantly lower in both treated (n = 15) and untreated leprosy patients (n = 14) when compared to controls (P < 0.001). Within leprosy patients, levels were lower in those who very recently developed disease (untreated group) when compared to already treated patients (P < 0.05). 25OH-vitamin D3 levels were not different between groups. The results suggest a potential association of cathelicidin LL-37 with Mycobacterium leprae infection. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：56 / 59

页数：4

共 23 条

[1]

Al Samie AR, 2004, LEPROSY REV, V75, P164

[2]

[Anonymous], 2008, Wkly Epidemiol Rec, V83, P293

[3] Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi [J].

Fitness, J ;

Floyd, S ;

Warndorff, DK ;

Sichali, L ;

Mwaungulu, L ;

Crampin, AC ;

Fine, PEM ;

Hill, AVS .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2004, 71 (03) :330-340

[4] Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immigrants from Sub-Saharan Africa [J].

Gibney, Katherine B. ;

MacGregor, Lachlan ;

Leder, Karin ;

Torresi, Joseph ;

Marshall, Caroline ;

Ebeling, Peter R. ;

Biggs, Beverley-Ann .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (03) :443-446

[5] Low Plasma Level of Cathelicidin Antimicrobial Peptide (hCAP18) Predicts Increased Infectious Disease Mortality in Patients Undergoing Hemodialysis [J].

Gombart, Adrian F. ;

Bhan, Ishir ;

Borregaard, Niels ;

Tamez, Hector ;

Camargo, Carlos A. ;

Koeffler, H. Phillip ;

Thadhani, Ravi .

CLINICAL INFECTIOUS DISEASES, 2009, 48 (04) :418-424

[6] Low plasma levels of the protein pro-LL-37 as an early indication of severe disease in patients with chronic neutropenia [J].

Karlsson, Jenny ;

Carlsson, Goran ;

Ramme, Kim Goransdotter ;

Hagglund, Hans ;

Nordenskjold, Magnus ;

Henter, Jan-Inge ;

Palmblad, Jan ;

Putsep, Katrin ;

Andersson, Mats .

BRITISH JOURNAL OF HAEMATOLOGY, 2007, 137 (02) :166-169

[7] IL-15 Links TLR2/1-Induced Macrophage Differentiation to the Vitamin D-Dependent Antimicrobial Pathway [J].

Krutzik, Stephan R. ;

Hewison, Martin ;

Liu, Philip T. ;

Robles, Juan Antonio ;

Stenger, Steffen ;

Adams, John S. ;

Modlin, Robert L. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (10) :7115-7120

[8] Innate immune responses to Mycobacterium ulcerans via toll-like receptors and dectin-1 in human keratinocytes [J].

Lee, Hye-Mi ;

Shin, Dong-Min ;

Choi, Dae-Kyoung ;

Lee, Zee-Won ;

Kim, Ki-Hye ;

Yuk, Jae-Min ;

Kim, Chang Deok ;

Lee, Jeung-Hoon ;

Jo, Eun-Kyeong .

CELLULAR MICROBIOLOGY, 2009, 11 (04) :678-692

[9] Cutting edge:: Vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin [J].

Liu, Philip T. ;

Stenger, Steffen ;

Tang, Dominic H. ;

Modlin, Robert L. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (04) :2060-2063

[10] Neutrophil-mediated innate immune resistance to mycobacteria [J].

Martineau, Adrian R. ;

Newton, Sandra M. ;

Wilkinson, Katalin A. ;

Kampmann, Beate ;

Hall, Bridget M. ;

Nawroly, Niga ;

Packe, Geoffrey E. ;

Davidson, Robert N. ;

Griffiths, Christopher J. ;

Wilkinson, Robert J. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (07) :1988-1994

← 1 2 3 →