MicroRNAs, cancer and cancer stem cells

被引：153

作者：

Zimmerman, Amy L. ^{[1
,3
]}

Wu, Shiyong ^{[1
,2
]}

机构：

[1] Ohio Univ, Dept Chem & Biochem, Athens, OH 45701 USA

[2] Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 USA

[3] Ohio Univ, Honors Tutorial Coll, Athens, OH 45701 USA

来源：

CANCER LETTERS | 2011年 / 300卷 / 01期

关键词：

MicroRNA; Stem cell; Cancer stem cell; RNAi technology; BCL-2 FAMILY PROTEINS; TUMOR-SUPPRESSOR P53; HUMAN LUNG CANCERS; PROSTATE-CANCER; PROSPECTIVE IDENTIFICATION; EXPRESSION PROFILES; MYELOID-LEUKEMIA; GENE-EXPRESSION; DOWN-REGULATION; NUCLEAR EXPORT;

D O I：

10.1016/j.canlet.2010.09.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs regulate self-renewal differentiation and division of cells via post-transcriptional gene silencing Aberrant microRNA levels specifically an overall downregulation are present in many cancers as compared to their normal tissue counterparts Therefore a potential therapeutic use of microRNAs is to correct these aberrant transcript levels involved in the signaling pathways of cancer This review focuses on the current knowledge of microRNAs and their involvement with cancer cells and cancer stem cells The methods currently being used to develop miRNA-based cancer therapeutics are examined and the limitations halting further progress are also discussed Published by Elsevier Ireland Ltd

引用

页码：10 / 19

页数：10

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