Evidence for a role for synaptophysin in expression of long-term potentiation in rat dentate gyrus

被引:67
|
作者
Mullany, PM [1 ]
Lynch, MA [1 ]
机构
[1] Univ Dublin Trinity Coll, Dept Physiol, Dublin 2, Ireland
关键词
dentate gyrus; glutamate release; LTP; synaptophysin; tyrphostin AG879;
D O I
10.1097/00001756-199808030-00012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
MAINTENANCE of long-term potentiation in perforant path-granule cell synapses is accompanied by increased glutamate release. Here we investigate the role of synaptophysin in release and in expression of long-term potentiation in dentate gyrus. We report that long-term potentiation was accompanied by increased endogenous glutamate release and increased tyrosine phosphorylation of synaptophysin, but these changes were attenuated when long-term potentiation was inhibited by the tyrosine kinase inhibitor tyrphostin AG879 or by the NMDA antagonist D-aminophosphonovalerate. In vitro analysis revealed that KCl-induced glutamate release was abolished in synaptosomes prepared in the presence of antisynaptophysin. The data suggest a role for synaptophysin in release and indicate that activation of tyrosine kinase and synaptophysin phosphorylation contribute to long-term potentiation perhaps by modulating glutamate release. NeuroReport 9: 2489-2494 (C) 1998 Rapid Science Ltd.
引用
收藏
页码:2489 / 2494
页数:6
相关论文
共 50 条