Dietary polystyrene nanoplastics exposure alters liver lipid metabolism and muscle nutritional quality in carnivorous marine fish large yellow croaker (Larimichthys crocea)

被引：114

作者：

Lai, Wencong ^{[1
]}

Xu, Dan ^{[1
]}

Li, Jiamin ^{[1
]}

Wang, Zhen ^{[1
]}

Ding, Yi ^{[1
]}

Wang, Xiuneng ^{[1
]}

Li, Xueshan ^{[1
]}

Xu, Ning ^{[1
]}

Mai, Kangsen ^{[1
,2
]}

Ai, Qinghui ^{[1
,2
]}

机构：

[1] Ocean Univ China, Key Lab Aquaculture Nutr & Feed, Key Lab Mariculture, Minist Educ,Minist Agr & Rural Affair, Qingdao 266003, Peoples R China

[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, 1 Wenhai Rd, Qingdao 266003, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2021年 / 419卷

基金：

中国国家自然科学基金;

关键词：

Nanoplastics (NPs); Dietary exposure; Lipid accumulation; Flesh texture; Fatty acid composition; GROWTH-PERFORMANCE; TROPHIC TRANSFER; FLESH QUALITY; MICROPLASTICS; ACCUMULATION; EXPRESSION; NANOPARTICLES; PEROXIDATION; HOMEOSTASIS; RESISTANCE;

D O I：

10.1016/j.jhazmat.2021.126454

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Nanoplastics (NPs) cause various adverse effects on marine fish. However, effects of dietary NPs exposure on liver lipid metabolism and muscle nutritional quality of carnivorous marine fish are not fully understood. In this study, a 21-day feeding test was conducted to simulate the food chain transfer of polystyrene nanoplastics (PS NPs) and then evaluate effects of different dietary PS NPs levels on the survival, growth performance, liver lipid metabolism, and muscle nutritional quality of large yellow croaker Larimichthys crocea. Results indicated that the survival and growth of large yellow croaker decreased with the increase of PS NPs levels. Moreover, PS NPs induced excessive liver lipid accumulation by down-regulating the expression of lipolysis-related genes and inhibiting the AMPK-PPAR alpha signaling pathway. In vitro, PS NPs could be accumulated in hepatocytes, reduce cell viability, and disrupt lipid metabolism of hepatocytes. Also, we found for the first time that PS NPs altered fatty acid composition and texture of fish muscle by enhancing oxidative stress and disrupting lipid metabolism. Overall, this study indicated that PS NPs induced liver lipid deposition by inhibiting lipolysis, and demonstrated that PS NPs altered the nutritional quality of fish, which might cause potential health effects for human consumers.

引用

页数：11

共 71 条

[1] Oxidative Stress and Metabolic Perturbations in Wooden Breast Disorder in Chickens [J].