Recurrent myelitis after allogeneic stem cell transplantation. Report of two cases

被引：15

作者：

Voss, Martin ^{[1
]}

Bischof, Felix ^{[1
]}

机构：

[1] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Gen Neurol, D-72076 Tubingen, Germany

来源：

BMC NEUROLOGY | 2010年 / 10卷

关键词：

COMPLICATIONS;

D O I：

10.1186/1471-2377-10-76

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Allogeneic and autologous haematopoietic stem cell transplantation are established treatment options for haematological malignancies and may possibly be employed to treat a range of genetic and autoimmune diseases. Case presentation: We report two patients who developed an acute myelitis within their thoracic spinal cord after allogeneic stem cell transplantation. Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide. Conclusions: Myelitis is a possibly disabling consequence of haematopoietic stem cell transplantation.

引用

页数：4

共 6 条

[1] Central nervous system immune reconstitution inflammatory syndrome (IRIS) after hematopoietic SCT [J].

Airas, L. ;

Paivarinta, M. ;

Roytta, M. ;

Karhu, J. ;

Kauppila, M. ;

Itala-Remes, M. ;

Remes, K. .

BONE MARROW TRANSPLANTATION, 2010, 45 (03) :593-596

[2] Once-daily intravenous busulfan and fludarabine: clinical and pharmacokinetic results of a myeloablative, reduced-toxicity conditioning regimen for allogeneic stem cell transplantation in AML and MDS [J].

de Lima, M ;

Couriel, D ;

Thall, PF ;

Wang, XM ;

Madden, T ;

Jones, R ;

Shpall, EJ ;

Shahjahan, M ;

Pierre, B ;

Giralt, S ;

Korbling, M ;

Russell, JA ;

Champlin, RE ;

Andersson, BS .

BLOOD, 2004, 104 (03) :857-864

[3] Spectrum and prognosis of neurologic complications after hematopoietic transplantation [J].

Denier, C. ;

Bourhis, J. -H. ;

Lacroix, C. ;

Koscielny, S. ;

Bosq, J. ;

Sigal, R. ;

Said, G. ;

Adams, D. .

NEUROLOGY, 2006, 67 (11) :1990-1997

[4] Bone-marrow transplantation fails to halt intrathecal lymphocyte activation in multiple sclerosis [J].

Mondria, T. ;

Lamers, C. H. J. ;

Boekhorst, P. A. W. te ;

Gratama, J. W. ;

Hintzen, R. Q. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2008, 79 (09) :1013-1015

[5] Stem cell transplantation for neurodegenerative diseases [J].

Rosser, Anne E. ;

Zietlow, Rike ;

Dunnett, Stephen B. .

CURRENT OPINION IN NEUROLOGY, 2007, 20 (06) :688-692

[6] Neurological complications of hematopoietic cell transplantation [J].

Saiz, A ;

Graus, F .

SEMINARS IN NEUROLOGY, 2004, 24 (04) :427-434

← 1 →