Pure Protein Microspheres by Calcium Carbonate Templating

被引：104

作者：

Volodkin, Dmitry V. ^{[1
]}

von Klitzing, Regine ^{[1
]}

Moehwald, Helmuth ^{[2
]}

机构：

[1] Tech Univ Berlin, Inst Chem, Stranski Lab Phys & Theoret Chem, Sekr TC 9, D-10623 Berlin, Germany

[2] Max Planck Inst Colloids & Interfaces, Dept Interfaces, D-14424 Potsdam, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 48期

关键词：

calcium carbonate; drug delivery; insulin; proteins; template synthesis; POROUS CACO3 MICROPARTICLES; POLYELECTROLYTE MICROCAPSULES; DRUG-DELIVERY; PULMONARY DELIVERY; ENCAPSULATION; INSULIN; ADSORPTION; PARTICLES; RELEASE; SYSTEM;

D O I：

10.1002/anie.201005089

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Swapping spheres: Monodisperse protein microspheres can be fabricated by templating on porous CaCO3 microcores (see picture; CaCO3 gray, insulin orange). The CaCO3 cores decompose upon variation of pH from 9.0 to 5.0, whereas the insulin model protein precipitates. The method requires mild conditions, no additives, and minimal processing. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9258 / 9261

页数：4

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