Mouthguard biosensor with telemetry system for monitoring of saliva glucose: A novel cavitas sensor

被引：250

作者：

Arakawa, Takahiro ^{[1
]}

Kuroki, Yusuke ^{[1
]}

Nitta, Hiroki ^{[1
]}

Chouhan, Prem ^{[2
]}

Toma, Koji ^{[1
]}

Sawada, Shin-ichi ^{[3
]}

Takeuchi, Shuhei ^{[4
]}

Sekita, Toshiaki ^{[4
]}

Akiyoshi, Kazunari ^{[3
]}

Minakuchi, Shunsuke ^{[4
]}

Mitsubayashi, Kohji ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Dept Biomed Devices & Instrumentat, Chiyoda Ku, 2-3-10 Kanda Surugadai, Tokyo 1010062, Japan

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, South Kensington Campus, London SW7 2AZ, England

[3] Kyoto Univ, Grad Sch Engn, Dept Polymer Chem, Nishikyo Ku, Kyoto 6158510, Japan

[4] Tokyo Med & Dent Univ, Gerodontol & Oral Rehabil, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138549, Japan

来源：

BIOSENSORS & BIOELECTRONICS | 2016年 / 84卷

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

Mouthguard; Biosensor; Glucose; Oral cavity; Saliva glucose; Glucose oxidase;

D O I：

10.1016/j.bios.2015.12.014

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We develop detachable "Cavitas sensors" to apply to the human oral cavity for non-invasive monitoring of saliva glucose. A salivary biosensor incorporating Pt and Ag/AgCl electrodes on a mouthguard support with an enzyme membrane is developed and tested. Electrodes are formed on the polyethylene terephthalate glycol (PETG) surface of the mouthguard. The Pt working electrode is coated with a glucose oxidase (GOD) membrane. The biosensor seamlessly is integrated with a glucose sensor and a wireless measurement system. When investigating in-vitro performance, the biosensor exhibits a robust relationship between output current and glucose concentration. In artificial saliva composed of salts and proteins, the glucose sensor is capable of highly sensitive detection over a range of 5-1000 mu mol/L of glucose, which encompasses the range of glucose concentrations found in human saliva. We demonstrate the ability of the sensor and wireless communication module to monitor saliva glucose in a phantom jaw imitating the structure of the human oral cavity. Stable and long-term real-time monitoring (exceeding 5 h) with the telemetry system is achieved. The mouthguard biosensor will be useful as a novel method for real-time non-invasive saliva glucose monitoring for better management of dental patients. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：106 / 111

页数：6

共 25 条

[11] Non-invasive mouthguard biosensor for continuous salivary monitoring of metabolites [J].