Miniaturisation of a capillary electrophoresis microchip for the sensing of endocrine disruptors

被引：3

作者：

Ha, K. ^{[1
]}

Joo, G-S ^{[1
]}

Jha, S. K. ^{[1
]}

Yeon, I-J ^{[2
]}

Kim, Y-S ^{[1
,3
]}

机构：

[1] Myongji Univ, Dept Nano Sci & Engn, Gyeonggi 449728, South Korea

[2] Chungju Natl Univ, Dept Environm Engn, Chungbuk 380702, South Korea

[3] Myongji Univ, Dept Elect Engn, Gyeonggi 449728, South Korea

来源：

IET NANOBIOTECHNOLOGY | 2010年 / 4卷 / 04期

关键词：

BISPHENOL-A; ELECTROCHEMICAL DETECTION; ELECTRODE; BPA;

D O I：

10.1049/iet-nbt.2010.0006

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Although capillary electrophoresis amperometric detector (CE-AD) involving double-T microchannel configuration is a powerful analytical tool in terms of sensitivity and selectivity, its long microchannel configuration hinders further miniaturisation. Therefore a twisted CE microchannel configuration was used in the present study to fabricate CE-AD devices for detection of endocrine disruptors. The analyte separation time varied slightly for the twisted microchannel structure, whereas the detector sensitivities were similar for the two configurations. The conventional indium tin oxide amperometric detector in the device with twisted microchannel configuration was later modified with Prussian blue to enhance the sensitivity of detection.

引用

页码：103 / 108

页数：6

共 26 条

[1] Analysis of glyphosate and aminomethylphosphonic acid by capillary electrophoresis with electrochemiluminescence detection [J].

Chiu, Hsien-Yi ;

Lin, Zhen-Yu ;

Tu, Hsin-Ling ;

Whang, Chen-Wen .

JOURNAL OF CHROMATOGRAPHY A, 2008, 1177 (01) :195-198

[2] Determination of bisphenol A in food-simulating liquids using LCED with a chemically modified electrode [J].

D'Antuono, A ;

Dall'Orto, VC ;

Lo Balbo, A ;

Sobral, S ;

Rezzano, I .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2001, 49 (03) :1098-1101

[3] End-to-End Differential Contact less Conductivity Sensor for Microchip Capillary Electrophoresis [J].

Fercher, Georg ;

Haller, Anna ;

Smetana, Walter ;

Vellekoopt, Michael J. .

ANALYTICAL CHEMISTRY, 2010, 82 (08) :3270-3275

[4] Monitoring of endocrine disruptors by capillary electrophoresis amperometric detector [J].

Ha, Kon ;

Joo, Gi-sung ;

Jha, Sandeep Kumar ;

Kim, Yong-Sang .

MICROELECTRONIC ENGINEERING, 2009, 86 (4-6) :1407-1410

[5] Amperometric detection of morphine at a Prussian blue-modified indium tin oxide electrode [J].

Ho, KC ;

Chen, CY ;

Hsu, HC ;

Chen, LC ;

Shiesh, SC ;

Lin, XZ .

BIOSENSORS & BIOELECTRONICS, 2004, 20 (01) :3-8

[6] Electrochemical cell lysis on a miniaturized flow-through device [J].

Jha, Sandeep Kumar ;

Ra, Gyu-Sik ;

Joo, Gi-Sung ;

Kim, Yong-Sang .

CURRENT APPLIED PHYSICS, 2009, 9 (04) :E301-E303

[7] A capillary electrophoresis microchip for amperometric detection of DNA [J].

Joo, Gi-Sung ;

Jha, Sandeep Kumar ;

Kim, Yong-Sang .

CURRENT APPLIED PHYSICS, 2009, 9 (04) :E222-E224

[8] A disposable thermopneumatic-actuated microvalve stacked with PDMS layers and ITO-coated glass [J].

Kim, JH ;

Na, KH ;

Kang, CJ ;

Jeon, D ;

Kim, YS .

MICROELECTRONIC ENGINEERING, 2004, 73-4 :864-869

[9] A disposable polydimethylsiloxane-based diffuser micropump actuated by piezoelectric-disc [J].

Kim, JH ;

Kang, CJ ;

Kim, YS .

MICROELECTRONIC ENGINEERING, 2004, 71 (02) :119-124

[10] Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons [J].

Le, Hoa H. ;

Carlson, Emily M. ;

Chua, Jason P. ;

Belcher, Scott M. .

TOXICOLOGY LETTERS, 2008, 176 (02) :149-156

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