Leptin and the regulation of body weight in mammals

被引：4233
作者：
Friedman, JM
Halaas, JL
机构：
[1] Rockefeller Univ, Mol Genet Lab, New York, NY 10021 USA
[2] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA
来源：
NATURE | 1998年 / 395卷 / 6704期
关键词：
D O I：
10.1038/27376
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The assimilation, storage and use of energy from nutrients constitute a homeostatic: system that is essential for life. In vertebrates, the ability to store sufficient quantities of energy-dense triglyceride in adipose tissue allows survival during the frequent periods of food deprivation encountered during evolution. However, the presence of excess adipose tissue can be maladaptive. A complex physiological system has evolved to regulate fuel stores and energy balance at an optimum level. Leptin, a hormone secreted by adipose tissue, and its receptor are integral components of this system. Leptin also signals nutritional status to several other physiological systems and modulates their Function. Here we review the role of leptin in the control of body weight and its relevance to the pathogenesis of obesity.
引用
收藏
页码：763 / 770
页数：8
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