Proliferation unleashed: The role of Skp2 in vascular smooth muscle cell proliferation

被引：14

作者：

Bond, Mark ^{[1
]}

Wu, Yih-Jer ^{[2
,3
,4
]}

机构：

[1] Univ Bristol, Bristol Heart Inst, Bristol Royal Infirm, Bristol BS2 8HW, Avon, England

[2] Natl Yang Ming Univ, Dept Cardiovasc Med & Med Res, Mackay Mem Hosp, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Dept Med, Mackay Med Coll, Taipei 112, Taiwan

[4] Natl Yang Ming Univ, Inst Tradit Med, Taipei 112, Taiwan

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2011年 / 16卷

关键词：

Skp2; Smooth Muscle Cell; Proliferation; p27; Cell-Cycle; Ubiquitin-Ligase; SCFSkp2; Neointima; Review; FOCAL ADHESION KINASE; SMALL-MOLECULE ANTAGONISTS; CYCLIN D1 EXPRESSION; UBIQUITIN-MEDIATED DEGRADATION; G1 PHASE PROGRESSION; BOX PROTEIN SKP2; KAPPA-B ACTIVITY; S-PHASE; EXTRACELLULAR-MATRIX; GROWTH-FACTOR;

D O I：

10.2741/3802

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular smooth muscle cell proliferation plays a major role in the development of numerous vascular pathologies. Understanding the molecular mechanisms that regulate smooth muscle cell proliferation is therefore essential for the development of new therapies for the treatment of these pathologies. Skp2 is an F-box protein component of the SCFSkp2 ubiquitin-ligase that controls cellular proliferation by regulating the ubiquitination and degradation of several cell-cycle regulatory proteins, including the cyclin-dependent kinase inhibitor, p27(Kip1). This review discusses the recent literature on the function and regulation of Skp2 in smooth muscle cells, which is emerging as a key player in the control of smooth muscle cell proliferation during vascular disease.

引用

页码：1517 / 1535

页数：19

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