Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice

被引：67

作者：

Wang, Ting ^{[1
]}

Takikawa, Yasuhiro ^{[1
]}

Satoh, Takumi ^{[2
]}

Yoshioka, Yoshichika ^{[4
]}

Kosaka, Kunio ^{[5
]}

Tatemichi, Yoshinori ^{[3
]}

Suzuki, Kazuyuki ^{[1
]}

机构：

[1] Iwate Med Univ, Dept Gastroenterol & Hepatol, Morioka, Iwate 0208505, Japan

[2] Iwate Med Univ, Fac Engn, Dept Welfare Engn, Morioka, Iwate 0208505, Japan

[3] Iwate Med Univ, Sch Med, Dept Pathol, Morioka, Iwate 0208505, Japan

[4] Osaka Univ, Immunol Frontier Res Ctr, Osaka, Japan

[5] Ctr Res & Dev, Tokyo, Japan

来源：

HEPATOLOGY RESEARCH | 2011年 / 41卷 / 01期

关键词：

carnosic acid; non-alcoholic fatty liver disease; ob; ob mice; obesity; FATTY LIVER-DISEASE; ACTIVATION; CELLS;

D O I：

10.1111/j.1872-034X.2010.00747.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Aim: Carnosic acid (CA) inhibits adipogenesis in vitro. The present study evaluated the therapeutic effects of CA in ob/ob mice. Methods: The experimental animals were given a standard chow diet with or without CA for 5 weeks. Bodyweight gain and food intake were measured during this period. Magnetic resonance imaging analysis, histological examination, serum chemistry analysis and intraperitoneal glucose tolerance test (IPGTT) were all performed. Results: The mice fed CA experienced significant weight loss and reduced visceral adiposity, in addition to significantly reduced serum triglyceride (TG) and cholesterol levels. Importantly, CA had a dramatic effect on the liver by reducing the hepatic TG content, thus decreasing serum alanine aminotransferase levels. In addition, IPGTT revealed that CA significantly improved glucose tolerance. Conclusion: These data suggest that CA is a novel therapeutic agent for obesity-related non-alcoholic fatty liver disease.

引用

页码：87 / 92

页数：6

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