Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout

被引:14
作者
Rasheed, Humaira [1 ,2 ]
Phipps-Green, Amanda J. [1 ]
Topless, Ruth [1 ]
Smith, Malcolm D. [3 ,4 ]
Hill, Catherine [5 ]
Lester, Susan [5 ]
Rischmueller, Maureen [5 ]
Janssen, Matthijs [6 ]
Jansen, Timothy L.
Joosten, Leo A. [8 ,9 ]
Radstake, Timothy R. [7 ,10 ]
Riches, Philip L. [11 ]
Tausche, Anne-Kathrin [12 ]
Liote, Frederic [13 ,14 ]
So, Alexander [15 ]
van Rij, Andre [16 ]
Jones, Gregory T. [16 ]
McCormick, Sally P. [1 ]
Harrison, Andrew A. [17 ]
Stamp, Lisa K. [18 ]
Dalbeth, Nicola [19 ]
Merriman, Tony R. [1 ]
机构
[1] Univ Otago, Dept Biochem, 710 Cumberland St, Dunedin 9054, New Zealand
[2] Univ Engn & Technol, Dept Chem, Lahore, Pakistan
[3] Flinders Med Ctr, Dept Med, Adelaide, SA, Australia
[4] Repatriat Gen Hosp, Adelaide, SA, Australia
[5] Queen Elizabeth Hosp, Dept Rheumatol, Woodville South, SA, Australia
[6] Rijnstate Hosp, Dept Rheumatol, Arnhem, Netherlands
[7] VieCuri Med Ctr, Dept IQ HealthCare, Venlo, Netherlands
[8] Radboud Univ Nijmegen Med Ctr, Dept Internal Med, Nijmegen, Netherlands
[9] Radboud Univ Nijmegen Med Ctr, Radboud Inst Mol Life Sci, Nijmegen, Netherlands
[10] Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Lab Translat Immunol, Utrecht, Netherlands
[11] Univ Edinburgh, Inst Genet & Mol Med, Rheumat Dis Unit, Edinburgh, Midlothian, Scotland
[12] Univ Clin Carl Gustav Carus, Dept Rheumatol, Dresden, Germany
[13] Hosp Lariboisiere, INSERM, UMR S 1132, Paris, France
[14] Univ Paris Diderot, Sorbonne Paris Cite, UFR Med, F-75205 Paris, France
[15] Univ Lausanne, DAL, Lab Rheumatol, Serv Rheumatol,CHUV, Nestle 05, CH-5029 Lausanne, Switzerland
[16] Univ Otago, Dept Surg, Dunedin, New Zealand
[17] Univ Otago, Dept Med, Wellington, New Zealand
[18] Univ Otago, Dept Med, Christchurch, New Zealand
[19] Univ Auckland, Dept Med, Auckland, New Zealand
关键词
gout; hyperuricaemia; gene; association; apolipoprotein; A-I GENE; C-III GENE; SERUM URATE; NEW-ZEALAND; URIC-ACID; HYPERTRIGLYCERIDEMIA; CIII; POLYMORPHISMS; CHOLESTEROL; PROMOTER;
D O I
10.1093/rheumatology/kew057
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. Gout is associated with dyslipidaemia. Association of the apolipoprotein A1-C3-A4 gene cluster with gout has previously been reported in a small study. To investigate a possible causal role for this locus in gout, we tested the association of genetic variants from APOA1 (rs670) and APOC3 (rs5128) with gout. Methods. We studied data for 2452 controls and 2690 clinically ascertained gout cases of European and New Zealand Polynesian (Maori and Pacific) ancestry. Data were also used from the publicly available Atherosclerosis Risk in Communities study (n = 5367) and the Framingham Heart Study (n = 2984). Multivariate adjusted logistic and linear regression was used to test the association of single-nucleotide polymorphisms with gout risk, serum urate, triglyceride and high-density lipoprotein cholesterol (HDL-C). Results. In Polynesians, the T-allele of rs670 (APOA1) increased (odds ratio, O R= 1.53, P = 4.9 x 10(-6)) and the G-allele of rs5128 (APOC3) decreased the risk of gout (OR = 0.86, P = 0.026). In Europeans, there was a strong trend to a risk effect of the T-allele for rs670 (OR = 1.11, P = 0.055), with a significant protective effect of the G-allele for rs5128 being observed after adjustment for triglycerides and HDL-C (OR = 0.81, P = 0.039). The effect at rs5128 was specific to males in both Europeans and Polynesians. Association in Polynesians was independent of any effect of rs670 and rs5128 on triglyceride and HDL-C levels. There was no evidence for association of either single-nucleotide polymorphism with serum urate levels (P >= 0.10). Conclusion. Our data, replicating a previous study, supports the hypothesis that the apolipoprotein A1-C3-A4 gene cluster plays a causal role in gout.
引用
收藏
页码:1421 / 1430
页数:10
相关论文
共 40 条
  • [1] NEW LOOK AT STATISTICAL-MODEL IDENTIFICATION
    AKAIKE, H
    [J]. IEEE TRANSACTIONS ON AUTOMATIC CONTROL, 1974, AC19 (06) : 716 - 723
  • [2] Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout
    Cardona, F
    Tinahones, FJ
    Collantes, E
    Escudero, A
    García-Fuentes, E
    Soriguer, FJ
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (01) : 85 - 88
  • [3] Increased level of MSU crystal-bound protein apolipoprotein A-I in acute gouty arthritis
    Chiang, S-L
    Ou, T-T
    Wu, Y-J
    Tu, H-P
    Lu, C-Y
    Huang, C-M
    Kuo, T-M
    Wang, T-N
    Chou, C-H
    Ko, Y-C
    [J]. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2014, 43 (06) : 498 - 502
  • [4] Dalbeth N, 2005, RHEUMATOLOGY, V44, P1090, DOI [10.1093/rheumatology/keh640, 10.1186/ar2952]
  • [5] AN APOLIPOPROTEIN CIII HAPLOTYPE PROTECTIVE AGAINST HYPERTRIGLYCERIDEMIA IS SPECIFIED BY PROMOTER AND 3' UNTRANSLATED REGION POLYMORPHISMS
    DAMMERMAN, M
    SANDKUIJL, LA
    HALAAS, JL
    CHUNG, W
    BRESLOW, JL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) : 4562 - 4566
  • [6] PROTEIN COFACTOR OF LECITHIN-CHOLESTEROL ACYLTRANSFERASE
    FIELDING, CJ
    FIELDING, PE
    SHORE, VG
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1972, 46 (04) : 1493 - &
  • [7] The renal urate transporter SLC17A1 locus: confirmation of association with gout
    Hollis-Moffatt, Jade E.
    Phipps-Green, Amanda J.
    Chapman, Brett
    Jones, Gregory T.
    van Rij, Andre
    Gow, Peter J.
    Harrison, Andrew A.
    Highton, John
    Jones, Peter B.
    Montgomery, Grant W.
    Stamp, Lisa K.
    Dalbeth, Nicola
    Merriman, Tony R.
    [J]. ARTHRITIS RESEARCH & THERAPY, 2012, 14 (02)
  • [8] Howie B, G3 BETHESDA
  • [9] Apolipoprotein A-I inhibits the production of interleukin-1β and tumor necrosis factor-α by blocking contact-mediated activation of monocytes by T lymphocytes
    Hyka, N
    Dayer, JM
    Modoux, C
    Kohno, T
    Edwards, CK
    Roux-Lombard, P
    Burger, D
    [J]. BLOOD, 2001, 97 (08) : 2381 - 2389
  • [10] JEENAH M, 1990, MOL BIOL MED, V7, P233