Current options and future perspectives in the treatment of patients with relapsed/refractory diffuse large B-cell lymphoma

被引：23

作者：

Frontzek, Fabian ^{[1
]}

Karsten, Imke ^{[1
]}

Schmitz, Norbert ^{[1
]}

Lenz, Georg ^{[1
]}

机构：

[1] Univ Hosp Munster, Dept Med A Hematol Oncol & Pneumol, D-48149 Munster, Germany

来源：

THERAPEUTIC ADVANCES IN HEMATOLOGY | 2022年 / 13卷

关键词：

ADC; ASCT; bispecific antibodies; CAR T-cells; DLBCL; monoclonal antibodies; targeted therapies; NON-HODGKIN-LYMPHOMA; CHEMOTHERAPY PLUS RITUXIMAB; RANDOMIZED CONTROLLED-TRIAL; ANTIBODY-DRUG CONJUGATE; CHOP-LIKE CHEMOTHERAPY; OPEN-LABEL; SINGLE-ARM; T-CELLS; R-CHOP; ALLOGENEIC TRANSPLANTATION;

D O I：

10.1177/20406207221103321

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) represents the most common subtype of aggressive lymphoma. Depending on individual risk factors, roughly 60-65% of patients can be cured by chemoimmunotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). However, patients with primary refractory disease or relapse (R/R) after an initial response are still characterized by poor outcome. Until now, transplant-eligible R/R DLBCL patients are treated with intensive salvage regimens followed by high-dose chemotherapy and autologous stem cell transplantation (ASCT) which, however, only cures a limited number of patients. It is most likely that in patients with early relapse after chemoimmunotherapy, chimeric antigen receptor (CAR) T-cells will replace high-dose chemotherapy and ASCT. So far, transplant-ineligible patients have mostly been treated in palliative intent. Recently, a plethora of novel agents comprising new monoclonal antibodies, antibody drug conjugates (ADC), bispecific antibodies, and CAR T-cells have emerged and have significantly improved outcome of patients with R/R DLBCL. In this review, we summarize our current knowledge on the usage of novel drugs and approaches for the treatment of patients with R/R DLBCL.

引用

页数：19

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