Rapid and label-free metamaterial-based biosensor for fatty acid detection with terahertz time-domain spectroscopy

被引：30

作者：

Tang, Mingjie ^{[1
,2
]}

Xia, Liangping ^{[1
,3
]}

Wei, Dongshan ^{[1
,4
]}

Yan, Shihan ^{[1
]}

Zhang, Mingkun ^{[1
]}

Yang, Zhongbo ^{[1
]}

Wang, Huabin ^{[1
]}

Du, Chunlei ^{[1
]}

Cui, Hong-Liang ^{[1
]}

机构：

[1] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multiscale Mfg Technol, Chongqing 400714, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Yangtze Normal Univ, Sch Elect Informat Engn, Chongqing 408100, Peoples R China

[4] Dongguan Univ Technol, Sch Elect Engn & Intelligentizat, Dongguan 523808, Guangdong, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2020年 / 228卷

基金：

中国国家自然科学基金;

关键词：

Fatty acid; Terahertz time-domain spectroscopy; Label-free; THz sensor; Dielectric constant; METHYL-ESTERS; FIELD ENHANCEMENT; MASS-SPECTRA; IDENTIFICATION; DNA; DERIVATIZATION; ABSORPTION;

D O I：

10.1016/j.saa.2019.117736

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A rapid method for detecting fatty acids (FAs) using terahertz time-domain spectroscopy (THz-TDS) technology combined with a metamaterial-based THz sensor was developed. We measured the THz responses to oleic acid, linoleic acid and alpha-linoleic acid with different numbers of double-bond, alpha-linoleic acid and gamma-linoleic acid with different conformations. In addition, in order to explore the reason for the observed redshifts of the resonance frequencies of the four FAs, the dielectric constants of the FAs were measured in the THz region. Furthermore, the four fatty acids were also attempted to be identified by Raman spectroscopy, which was difficult to accomplish unambiguously because of the effect of fluorescence. This result thus demonstrates the power and usefulness of metamaterial-assisted THz-TDS in the rapid determination of the FAs, and its potential as a versatile tool for investigation of biological metabolism, and for food product quality, safety inspection and control. (C) 2019 Published by Elsevier B.V.

引用

页数：5

共 40 条

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