Role of three chitin synthase genes in the growth of Candida albicans

被引：96

作者：

Mio, T

Yabe, T

Sudoh, M

Satoh, Y

Nakajima, T

Arisawa, M

YamadaOkabe, H

机构：

[1] NIPPON ROCHE RES CTR,DEPT MYCOL,KAMAKURA,KANAGAWA 247,JAPAN

[2] TOHOKU UNIV,FAC AGR,DEPT APPL BIOCHEM,SENDAI,MIYAGI 981,JAPAN

来源：

JOURNAL OF BACTERIOLOGY | 1996年 / 178卷 / 08期

关键词：

D O I：

10.1128/jb.178.8.2416-2419.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The CHS2 and CHS3 genes of Candida albicans were disrupted. The double disruptant was still viable. Assessment of chitin and of calcofluor white resistance shows that CHS1 is responsible for septum formation and CHS3 is responsible for overall chitin synthesis otherwise. There were only small differences in virulence to immunocompromised mice of homozygous chs2 Delta and homozygous chs3 Delta null mutants.

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页码：2416 / 2419

页数：4

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