A pathogenic parasite interferes with phagocytosis of insect immunocompetent cells

被引：37

作者：

Brivio, Maurizio F. ^{[1
]}

Mastore, Maristella ^{[1
]}

Nappi, Anthony J. ^{[2
]}

机构：

[1] Univ Insubria, Lab Comparat Immunol, DBSF, I-21100 Varese, Italy

[2] Loyola Univ, Dept Biol, Chicago, IL 60626 USA

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2010年 / 34卷 / 09期

关键词：

Phagocytosis; Nematode; PRRs; PAMPs; Cuticle; Insect; Immunosuppression; HIPs; GREATER WAX MOTH; GALLERIA-MELLONELLA; APOLIPOPHORIN-III; STEINERNEMA-FELTIAE; ENTOMOPATHOGENIC NEMATODES; SCHISTOSOMA-MANSONI; HEMOLYMPH-PROTEINS; IMMUNE-RESPONSE; INNATE IMMUNITY; SURFACE-LIPIDS;

D O I：

10.1016/j.dci.2010.05.002

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Phagocytosis activity of hemocytes of the host Gallerin mellonella (Lepidoptera) was modulated by the infection of the entomopathogenic nematode Steinernema feltiae (Rahbditida) and was found to be correlated with the opsonization of bacteria by hemolymph factors. The presence of nematodes resulted in a significative decrease in phagocytosis of bacteria by host hemocytes, both in in vivo and in in vitro assays. Host interacting proteins (HIPs), which appear to function as opsonic factors and are essential to perform immune responses, were removed by S. feltiae from host hemolymph, by means of its epicuticle binding properties. Host humoral factors sequestered by the parasite have been identified by monodimensional and 2D electrophoretic analysis. The data suggest that S. feltiae, living in association with symbiontic bacteria (Xenorhabdus nematophilus), develop an immune suppressive strategy to support its bacteria, which diminished the effectiveness of immunological surveillance by the host. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：991 / 998

页数：8

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