Chemical composition differentiation of Shen-Shuai-Ning granule between combined decoction and separated decoction using HPLC-DAD-ESI-QTOF-MS

被引：6

作者：

Liu, Jianli ^{[1
]}

Zhang, Yu ^{[1
]}

Hao, Yimeng ^{[1
]}

Zhao, Ying ^{[1
]}

Li, Yanjiao ^{[1
]}

Qin, Rulan ^{[1
]}

Lv, Chongning ^{[1
]}

Lu, Jincai ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

来源：

BIOMEDICAL CHROMATOGRAPHY | 2017年 / 31卷 / 09期

关键词：

chemical composition identification; combined decoction and separated decoction; HPLC-Dad-ESI-QTOF/MS; Shen Shuai Ning; PERFORMANCE LIQUID-CHROMATOGRAPHY; FLIGHT MASS-SPECTROMETRY; DIODE-ARRAY DETECTION; DITERPENOID CONSTITUENTS; SALVIA-MILTIORRHIZA; TIME; IDENTIFICATION; RADIX; MECHANISM; COPTIDIS;

D O I：

10.1002/bmc.3949

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Shen-Shuai-Ning (SSN) granule, a traditional Chinese medicine formula, is widely used in clinical practice for treating chronic renal failure. However, its detailed chemical profile is unknown. Here, HPLC-ESI-QTOF-MS was employed for the systematic chemical analysis of SSN. A total of 52 compounds were identified and the characteristic ions of the compounds were described. Furthermore, chemical consistency between the combined decoction and the separated decoction of SSN was evaluated using HPLC-DAD. A chemical comparison between two preparations of SSN granule (combined decoction and separated decoction of Coptides Rhizoma) indicated a significant difference in the content of many compounds, including salvianolic acid A, salvianolic acid B, berberine, palmatine and epiberberine. As a result, separated decoction of Coptides Rhizoma would lead to a significantly decrease in depsides in Salviae Miltiorrhizae Radix et Rhizoma and an increase in alkaloids in Coptidis Rhizoma.

引用

页数：10

共 41 条

[11] An activity-integrated strategy involving ultra-high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and fraction collector for rapid screening and characterization of the α-glucosidase inhibitors in Coptis chinensis Franch. (Huanglian) [J].

Ge, Ai-hua ;

Bai, Yang ;

Li, Jin ;

Liu, Jiao ;

He, Jun ;

Liu, Er-wei ;

Zhang, Peng ;

Zhang, Bo-li ;

Gao, Xiu-mei ;

Chang, Yan-xu .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 100 :79-87

[12]

[郭锦明 Guo Jinming], 2011, [中成药, Chinese Traditional Patent Medicine], V33, P110

[13] Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution [J].

Guo, Yong-Xue ;

Xiu, Zhi-Long ;

Zhang, Dai-Jia ;

Wang, Hui ;

Wang, Long-Xing ;

Xiao, Hong-Bin .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007, 43 (04) :1249-1255

[14] Anti-angiogenic effects of rhubarb and its anthraquinone derivatives [J].

He, Zhi-Heng ;

He, Ming-Fang ;

Ma, Shuang-Cheng ;

But, Paul Pui-Hay .

JOURNAL OF ETHNOPHARMACOLOGY, 2009, 121 (02) :313-317

[15] Matrix solid-phase dispersion extraction followed by high performance liquid chromatography-diode array detection and ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometer method for the determination of the main compounds from Carthamus tinctorius L. (Hong-hua) [J].

Hong, Bo ;

Wang, Zhe ;

Xu, Tianjiao ;

Li, Chengchong ;

Li, Wenjing .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2015, 107 :464-472

[16]

[霍志鹏 Huo Zhipeng], 2012, [中成药, Chinese Traditional Patent Medicine], V34, P1901

[17]

Jiang H. P., 2013, J SHANDONG U TRADITI, V2, P166

[18]

Li SJ, 2007, SPECTROSC SPECT ANAL, V27, P730

[19] Development of the fingerprints for the quality of the roots of Salvia miltiorrhiza and its related preparations by HPLC-DAD and LC-MSn [J].

Liu, Ai-Hua ;

Lin, Yan-Hua ;

Yang, Min ;

Guo, Hui ;

Guan, Shu-Hong ;

Sun, Jiang-Hao ;

Guo, De-An .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007, 846 (1-2) :32-41

[20] Characterization and identification of multiple constituents in Yinhuang granules by high-performance liquid chromatography with diode-array and time-of-flight mass spectrometry detection [J].

Liu, E-Hu ;

Liu, Qun ;

Chu, Chu ;

Li, Ping .

JOURNAL OF SEPARATION SCIENCE, 2011, 34 (19) :2566-2575

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