MiR-219-5p Inhibits the Growth and Metastasis of Malignant Melanoma by Targeting BCL-2

被引：32

作者：

Long, Jianwen ^{[1
,2
,3
]}

Menggen, Qiqige ^{[4
]}

Wuren, Qimige ^{[4
]}

Shi, Quan ^{[2
,3
]}

Pi, Xianming ^{[2
,3
]}

机构：

[1] Hubei Univ Chinese Med, Sch Clin Med 1, Dept Dermatol, Wuhan, Hubei, Peoples R China

[2] Hubei Prov Hosp Tradit Chinese Med, Dept Dermatol, Wuhan, Peoples R China

[3] Hubei Prov Acad Tradit Chinese Med, Dept Dermatol, Wuhan, Hubei, Peoples R China

[4] Mongolian Med Hosp, Dept Dermatol, Bortala Mongol Autonomou, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2017年 / 2017卷

关键词：

CANCER; IMMUNOTHERAPY; EXPRESSION; MICRORNAS; INVASION; ROLES; CELLS;

D O I：

10.1155/2017/9032502

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Malignant melanoma is a very dangerous tumor which is resistant to conventional therapy. MicroRNA exerts a vital function in promoting or inhibiting tumor development. The research has investigated the expression and function of miR-219-5p inmelanoma. As a result, miR-219-5p expression was distinctly reduced inmelanoma tissues and cell lines and was negatively correlated with Bcl-2 protein level in melanoma. Patients with low miR-219-5p level represented obviously a low overall survival in comparison with patients with high miR-219-5p level. The upregulation of miR-219-5p inhibited melanoma growth and metastasis and strengthened melanoma cells chemosensitivity by targeting Bcl-2. Therefore, the modulation of miR-219-5p expression may be a novel treatment strategy in melanoma.

引用

页数：7

共 21 条

[1] The use of immunotherapy in the treatment of melanoma [J].

Achkar, Tala ;

Tarhini, Ahmad A. .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2017, 10

[2] The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma [J].

Aftab, Muhammad Nauman ;

Dinger, Marcel E. ;

Perera, Ranjan J. .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2014, 563 :60-70

[3] miR-219-5p plays a tumor suppressive role in colon cancer by targeting oncogene Sall4 [J].

Cheng, Ji ;

Deng, Rui ;

Zhang, Peng ;

Wu, Chuanqing ;

Wu, Ke ;

Shi, Liang ;

Liu, Xinghua ;

Bai, Jie ;

Deng, Meizhou ;

Shuai, Xiaoming ;

Gao, Jinbo ;

Wang, Guobin ;

Tao, Kaixiong .

ONCOLOGY REPORTS, 2015, 34 (04) :1923-1932

[4] Bcl-2 promotes invasion and lung metastasis by inducing matrix metalloproteinase-2 [J].

Choi, J ;

Choi, K ;

Benveniste, EN ;

Hong, YS ;

Lee, JH ;

Kim, J ;

Park, K .

CANCER RESEARCH, 2005, 65 (13) :5554-5560

[5] Adjuvant immunotherapy of melanoma and development of new approaches using the neoadjuvant approach [J].

Davar, Diwakar ;

Tarhini, Ahmad A. ;

Kirkwood, John M. .

CLINICS IN DERMATOLOGY, 2013, 31 (03) :237-250

[6]

Hoek KS, 2009, GIORN ITAL DERMAT V, V144, P39

[7]

Hulstaert E., 2017, ONCOTARGET

[8] Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy [J].

Kang, Min H. ;

Reynolds, C. Patrick .

CLINICAL CANCER RESEARCH, 2009, 15 (04) :1126-1132

[9]

Klingenberg M., 2017, J HEPATOLOGY

[10] MicroRNA-219-5p Represses the Proliferation, Migration, and Invasion of Gastric Cancer Cells by Targeting the LRH-1/Wnt/β-Catenin Signaling Pathway [J].

Li, Chunsheng ;

Dong, Jingrong ;

Han, Zhenqi ;

Zhang, Kai .

ONCOLOGY RESEARCH, 2017, 25 (04) :617-627

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