Regulation of phospholipase C-delta by GTP-binding proteins-rhoA as an inhibitory modulator

被引：19
作者：
Hodson, EAM
Ashley, CC
Hughes, AD
Lymn, JS
机构：
[1] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England
[2] St Marys Hosp, Imperial Coll Sch Med, Dept Clin Pharmacol, London W2 1NY, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1998年 / 1403卷 / 01期
关键词：
phospholipase C delta 1; GTP-binding protein; exoenzyme C3; rhoA;
D O I：
10.1016/S0167-4889(98)00028-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The regulation of Phospholipase C (PLC)delta activity remains obscure. These studies show that PLC delta(1) activity is significantly enhanced by both guanosine thiotriphosphate (GTP gamma S) and Clostridium botulinum exoenzyme C3 (C3) but not by aluminium fluoride. C3 ADP ribosylated a 21-kDa protein in the PLC delta(1) preparation and Western blotting identified rhoA in these samples. RhoA acts as an inhibitory modulator of PLC delta activity. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：97 / 101
页数：5
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