Brain iron overload following intracranial haemorrhage

被引:110
作者
Garton, Thomas [1 ]
Keep, Richard F. [1 ]
Hua, Ya [1 ]
Xi, Guohua [1 ]
机构
[1] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
基金
美国国家卫生研究院;
关键词
Brain; Hemorrhage; Subarachnoid; AMYLOID PRECURSOR PROTEIN; EXPERIMENTAL SUBARACHNOID HEMORRHAGE; INTRACEREBRAL HEMORRHAGE; INTRAVENTRICULAR HEMORRHAGE; NEURONAL APOPTOSIS; CEREBROSPINAL-FLUID; OXIDATIVE STRESS; UP-REGULATION; MITOCHONDRIAL FRAGMENTATION; INTRAVENOUS MINOCYCLINE;
D O I
10.1136/svn-2016-000042
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Intracranial haemorrhages, including intracerebral haemorrhage (ICH), intraventricular haemorrhage (IVH) and subarachnoid haemorrhage (SAH), are leading causes of morbidity and mortality worldwide. In addition, haemorrhage contributes to tissue damage in traumatic brain injury (TBI). To date, efforts to treat the long-term consequences of cerebral haemorrhage have been unsatisfactory. Incident rates and mortality have not showed significant improvement in recent years. In terms of secondary damage following haemorrhage, it is becoming increasingly apparent that blood components are of integral importance, with haemoglobin-derived iron playing a major role. However, the damage caused by iron is complex and varied, and therefore, increased investigation into the mechanisms by which iron causes brain injury is required. As ICH, IVH, SAH and TBI are related, this review will discuss the role of iron in each, so that similarities in injury pathologies can be more easily identified. It summarises important components of normal brain iron homeostasis and analyses the existing evidence on iron-related brain injury mechanisms. It further discusses treatment options of particular promise.
引用
收藏
页码:172 / 184
页数:13
相关论文
共 218 条
[81]  
Karwacki Z, 2005, Folia Morphol (Warsz), V64, P248
[82]   The Choroid Plexus in Healthy and Diseased Brain [J].
Kaur, Charanjit ;
Rathnasamy, Gurugirijha ;
Ling, Eng-Ang .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2016, 75 (03) :198-213
[83]   Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease [J].
Kaur, D ;
Yantiri, F ;
Rajagopalan, S ;
Kumar, J ;
Mo, JO ;
Boonplueang, R ;
Viswanath, V ;
Jacobs, R ;
Yang, L ;
Beal, MF ;
DiMonte, D ;
Volitaskis, I ;
Ellerby, L ;
Cherny, RA ;
Bush, AI ;
Andersen, JK .
NEURON, 2003, 37 (06) :899-909
[84]   Brain iron metabolism: Neurobiology and neurochemistry [J].
Ke, Ya ;
Qian, Zhong Ming .
PROGRESS IN NEUROBIOLOGY, 2007, 83 (03) :149-173
[85]   Intracerebral haemorrhage: mechanisms of injury and therapeutic targets [J].
Keep, Richard F. ;
Hua, Ya ;
Xi, Guohua .
LANCET NEUROLOGY, 2012, 11 (08) :720-731
[86]   TETRACYCLINES [J].
KLEIN, NC ;
CUNHA, BA .
MEDICAL CLINICS OF NORTH AMERICA, 1995, 79 (04) :789-801
[87]   The pathology of superficial siderosis of the central nervous system [J].
Koeppen, Arnulf H. ;
Michael, Susan C. ;
Li, Danhong ;
Chen, Zewu ;
Cusack, Matthew J. ;
Gibson, Walter M. ;
Petrocine, Simone V. ;
Qian, Jiang .
ACTA NEUROPATHOLOGICA, 2008, 116 (04) :371-382
[88]   Intravenous Minocycline in Acute Stroke A Randomized, Controlled Pilot Study and Meta-analysis [J].
Kohler, Edith ;
Prentice, David A. ;
Bates, Timothy R. ;
Hankey, Graeme J. ;
Claxton, Anne ;
van Heerden, Jolandi ;
Blacker, David .
STROKE, 2013, 44 (09) :2493-2499
[89]   Potential role of statins in the intracerebral hemorrhage and subarachnoid hemorrhage [J].
Kotlega, Dariusz ;
Golab-Janowska, Monika ;
Masztalewicz, Marta ;
Ciecwiez, Sylwester ;
Nowacki, Przemyslaw .
NEUROLOGIA I NEUROCHIRURGIA POLSKA, 2015, 49 (05) :322-328
[90]  
Kress GJ, 2002, J NEUROSCI, V22, P5848