Synthesis of L- and D-β-3′-deoxy-3′,3′-difluoronucleosides

被引：20

作者：

Xu, XH

Qiu, XL

Zhang, XG

Qing, FL

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[2] Donghua Univ, Inst Biol Sci & Biotechnol, Shanghai 201620, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 07期

关键词：

D O I：

10.1021/jo052652h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both (L)- and D-beta-3'-deoxy-3',3'-difluoronucleosides were synthesized starting from the key intermediate difluorohomoallyl alcohol 11. Deoxo-Fluor was accidentally found to be efficient in reversing the hydroxyl configuration of 34, and the desired product 41 was provided in good yield.

引用

页码：2820 / 2824

页数：5

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