A simple method for the preparation of di-, tri- and tetrasubstituted non-symmetrical ureas

被引：16

作者：

Bridgeman, E ^{[1
]}

Tomkinson, NCO ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, Wales

来源：

SYNLETT | 2006年 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

urea; microwave-assisted synthesis; carbamate;

D O I：

10.1055/s-2005-923584

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a series of di-, tri- and tetrasubstituted non-symmetrical ureas is described. Di- and trisubstituted ureas are prepared in excellent yield by treatment of a phenyl carbamate in a self-tunable single-mode microwave synthesizer with a primary or secondary amine. The synthetically more challenging tetrasubstituted urea can be prepared using the 4-nitrophenyl carbamate and a secondary amine.

引用

收藏

页码：243 / 246

页数：4

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