Structure elucidation of two new xanthone derivatives from the marine fungus Penicillium sp (ZZF 32#) from the South China Sea

被引：50

作者：

Shao, Changlun ^{[1
,2
]}

Wang, Changyun ^{[2
]}

Wei, Meiyan ^{[3
]}

Gu, Yucheng ^{[4
]}

Xia, Xuekui ^{[1
]}

She, Zhigang ^{[1
]}

Lin, Yongcheng ^{[1
]}

机构：

[1] Sun Yat Sen Zhongshan Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

[2] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China

[3] Guangdong Med Coll, Sch Pharm, Dongguan 523808, Peoples R China

[4] Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2008年 / 46卷 / 11期

基金：

中国国家自然科学基金;

关键词：

NMR; H-1; C-13; 2D NMR; xanthone; mangrove fungus; structure elucidation;

D O I：

10.1002/mrc.2293

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new xanthones, 8-(methoxycarbonyl)-1-hydroxy-9-oxo-9H-xanthene-3-carboxylic acid (1) and dimethyl 8-methoxy-9-oxo-9H-xanthene-1, 6-dicarboxylate (2) and one known xanthone methyl 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (3) were isolated from the culture broth of the mangrove fungus Penicillium sp. (ZZF 32#) collected from the South China Sea. Their structures were established by comprehensive analysis of one-dimensional (1D) and two-dimensional (2D) NMR data. The structure of compound 3 was confirmed by X-ray crystallography, which led to the suggestion that janthinone (4) might have the same structure as 3. Compounds 1-3 were inactive against KB or KBv200 cells during cytotoxicity evaluations. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：1066 / 1069

页数：4

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