Defined Hypervalent Iodine(III) Reagents Incorporating Transferable Nitrogen Groups: Nucleophilic Amination through Electrophilic Activation

被引：115

作者：

Souto, Jose A. ^{[1
]}

Martinez, Claudio ^{[1
]}

Velilla, Irene ^{[1
]}

Muniz, Kilian ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 04期

关键词：

amides; amination; iodine(III) reagents; nucleophilicity; oxidation; METAL-FREE CONDITIONS; N BOND FORMATION; CYCLOFUNCTIONALIZATION TOTAL-SYNTHESIS; TRIISOPROPYLSILYL ENOL ETHERS; ACID-CATALYZED REARRANGEMENT; BETA-AZIDO FUNCTIONALIZATION; MEDIATED ALKYNE AMIDATION; POLYVALENT IODINE; C-H; TRIMETHYLSILYL AZIDE;

D O I：

10.1002/anie.201206420

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Only I and N: Hypervalent iodine(III) reagents with two reactive I-N single bonds have been isolated for the first time. Their solid-state and solution structures provide evidence for enhanced electrophilicity at iodine and nucleophilic character of the imine. As a result, improved reactivity in amination reactions and unprecedented nitrogen-transfer reactions under metal-free conditions are realized. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1324 / 1328

页数：5

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