Rhodium-Catalyzed Enantioselective Addition to Unsymmetrical α-Diketones: Tandem One-Pot Synthesis of Optically Active 3-Tetrasubstituted Isochroman Derivatives

被引：41

作者：

Zhu, Ting-Shun ^{[1
]}

Chen, Jian-Ping ^{[1
]}

Xu, Ming-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 03期

基金：

中国国家自然科学基金;

关键词：

AC-7954; asymmetric catalysis; domino reactions; isochromans; rhodium; ARYL BORONIC ACIDS; OLEFIN LIGANDS; STEREOSELECTIVE-SYNTHESIS; RECEPTOR ANTAGONIST; DISCOVERY; 1,2-ADDITION;

D O I：

10.1002/chem.201203701

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The domino effect: An efficient and general catalytic one-pot synthesis of quaternary-substituted isochroman derivatives has been developed (see scheme). The cascade transformation relies on rhodium-catalyzed highly regio- and enantioselective 1,2-addition of arylboronic acids to unsymmetrical α-diketones and intramolecular etherification or esterification, and provides a variety of enantioenriched isochromanones under exceptionally mild conditions. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：865 / 869

页数：5

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