In situ formation of biodegradable dextran-based hydrogel via Michael addition

被引：11

作者：

Peng, Geng ^{[1
,2
]}

Wang, Jing ^{[1
,2
]}

Yang, Fan ^{[1
,2
]}

Zhang, Shuo ^{[2
]}

Hou, Juan ^{[2
,3
]}

Xing, Wanli ^{[2
]}

Lu, Xun ^{[1
]}

Liu, Changsheng ^{[1
,2
,3
]}

机构：

[1] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China

[3] E China Univ Sci & Technol, Key Lab Ultrafine Mat Educ, Shanghai 200237, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2013年 / 127卷 / 01期

基金：

中国国家自然科学基金;

关键词：

hydrogel; biomaterials; biodegradable; rheology; biocompatibility; DEGRADATION; RELEASE; PROTEINS; CELLS; GEL;

D O I：

10.1002/app.37825

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Vinyl-sulfone-functionalized dextran (Dex-VS) was readily prepared by a single-batch synthetic procedure at room temperature. The thiol molecule, 1,4-dithioerythritol (DTE, commercially available) with two terminal thiol groups was used as crosslinking agent. Hydrogels were rapidly prepared in situ by Michael addition under mild physiological conditions. Properties including gelation duration, mechanical modulus, and degradation behavior could be expediently controlled. Moreover, the hydrogels had comparatively low cytotoxicity, and the in vivo tests demonstrated an effective delivery of growth factor. This study might provide a powerful material to be used in tissue regeneration. (C) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2012

引用

页码：577 / 584

页数：8

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