Epidemiology, natural history and risk factors for anal intraepithelial neoplasia

被引：20
作者：
Coutlee, Francois [1 ,2 ,3 ,4 ]
de Pokomandy, Alexandra [5 ,6 ]
Franco, Eduardo L. [4 ]
机构：
[1] Ctr Hosp Univ Montreal, Dept Microbiol, Montreal, PQ H2L 4M1, Canada
[2] Ctr Hosp Univ Montreal, Dept Infectiol, Montreal, PQ H2L 4M1, Canada
[3] Univ Montreal, Dept Microbiol & Immunol, Montreal, PQ H3T 1J4, Canada
[4] McGill Univ, Div Canc Epidemiol, Montreal, PQ H2W 1S6, Canada
[5] McGill Univ, Ctr Hlth, Immunodeficiency Serv, Dept Med, Montreal, PQ H2X 2P4, Canada
[6] McGill Univ, Dept Family Med, Montreal, PQ H2X 2P4, Canada
来源：
SEXUAL HEALTH | 2012年 / 9卷 / 06期
基金：
加拿大健康研究院;
关键词：
HIV; human papillomavirus; intraepithelial lesions; men who have sex with men; HUMAN-PAPILLOMAVIRUS INFECTION; HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; HIGH-RESOLUTION ANOSCOPY; HIV-POSITIVE MEN; CYTOLOGIC ABNORMALITIES; HOMOSEXUAL-MEN; HPV INFECTION; HIGH PREVALENCE; CANCER PRECURSORS;
D O I：
10.1071/SH11167
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Studies conducted in HIV-seropositive individuals have enhanced our understanding of the natural history of anal intraepithelial neoplasia (AIN) and of factors predictive of progression to high-grade AIN, the immediate precursor to anal cancer. AIN is frequently detected in HIV-seropositive individuals. Factors that increase the risk for AIN include HIV infection, low current or nadir blood CD4+ cell counts, receptive anal intercourse, oncogenic human papillomavirus (HPV) infection, persistent anal HPV infection, multiple HPV type infections and high anal HPV viral load. This review confirms the importance of high-grade AIN in HIV-seropositive individuals and HIV-seronegative men having sex with men.
引用
收藏
页码：547 / 555
页数：9
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