mBin1b transgenic mice show enhanced resistance to epididymal infection by bacteria challenge

被引：27
作者：
Fei, Z. [2 ]
Hu, S.
Xiao, L.
Zhou, J. [2 ]
Diao, H. [4 ]
Yu, H. [4 ]
Fang, S. [2 ]
Wang, Y. [2 ]
Wan, Y. [2 ]
Wang, W. [2 ,3 ]
He, Y. [2 ]
Wang, C.
Xu, G. [2 ]
Wang, Z. [2 ]
Zhang, Y. [1 ]
Fei, J. [2 ,3 ]
机构：
[1] SIBS, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai Key Lab Mol Androl, Shanghai 200031, Peoples R China
[2] Shanghai Res Ctr Model Organisms, Shanghai, Peoples R China
[3] Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China
[4] Shanghai Inst Planned Parenthood Res, NPFPC Key Lab Contracept & Devices, Shanghai, Peoples R China
来源：
GENES AND IMMUNITY | 2012年 / 13卷 / 06期
关键词：
antimicrobial peptide; defensin; mBin1b; transgenic; epididymis; fertility; BETA-DEFENSIN; EXPRESSION; IDENTIFICATION; TRACT; GENE; PROMOTER; FAMILY;
D O I：
10.1038/gene.2012.13
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The mBin1b is a beta-defensin gene identified in the mouse epididymis. In the current report, its expression pattern and antibacterial activities were characterized, and a transgenic (TG) mouse model was developed in which mBin1b was exclusively overexpressed by up to 50-fold over normal levels in the caput epididymis. The experimental animals are healthy with normal reproductive activity, but are more resistant to epididymal infection from Escherichia coli than normal animals. The expression of IL1 alpha and IL1 beta in the epididymis was decreased in the TG mice, which suggests that mBin1b has a role in the regulation of inflammatory response in the epididymis.
引用
收藏
页码：445 / 451
页数：7
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