Long-term results after 12-year follow-up of patients treated with whole-breast and boost irradiation after breast-conserving surgery

被引:3
作者
Takahashi, Shigeo [1 ,2 ]
Murakami, Yuji [1 ]
Imano, Nobuki [1 ]
Kaneyasu, Yuko [1 ,3 ]
Doi, Yoshiko [1 ]
Kenjo, Masahiro [1 ]
Kimura, Tomoki [1 ]
Kadoya, Takayuki [4 ,5 ]
Arihiro, Koji [6 ]
Kataoka, Tsuyoshi [4 ]
Okada, Morihito [4 ,5 ]
Nagata, Yasushi [1 ]
机构
[1] Hiroshima Univ, Grad Sch Biomed Sci, Dept Radiat Oncol, Hiroshima, Japan
[2] Kagawa Univ Hosp, Dept Radiat Oncol, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan
[3] Natl Hosp Org, Dept Radiotherapy, Fukuyama Med Ctr, Hiroshima, Japan
[4] Hiroshima Univ Hosp, Dept Breast Surg, Hiroshima, Japan
[5] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Surg Oncol, Hiroshima, Japan
[6] Hiroshima Univ Hosp, Dept Anat Pathol, Hiroshima, Japan
关键词
Breast cancer; Breast-conserving therapy; Whole-breast irradiation; Boost irradiation; Long-term outcome; LOCAL RECURRENCE; CONSERVATION TREATMENT; CANCER; STAGE; THERAPY; WOMEN; RISK; CARCINOMA;
D O I
10.1007/s11604-016-0562-2
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The long-term outcomes of whole-breast and boost irradiation after breast-conserving surgery (BCS) for patients with breast cancer were retrospectively analyzed. Patients who received whole-breast and boost irradiation after BCS from 1990 to 2002 were included. Boost irradiation was administered to each tumor bed, regardless of the surgical margin status. The median doses of whole-breast and boost irradiation were 45 Gy in 25 fractions (range 36-45 Gy), and 14 Gy in 7 fractions (range 0-14 Gy), respectively. Data for 306 patients were analyzed. With a median follow-up time of 144 months, the 10-year overall survival, disease-free survival, ipsilateral breast tumor recurrence (IBTR), and metachronous contralateral breast cancer (MCBC) occurrence rates were 93.0, 84.1, 2.1, and 4.1 %, respectively. In the multivariate analysis, pT2 was a significant risk factor for IBTR (p = 0.041), while age aecurrency sign 50 years and pT2 were significant risk factors for MCBC occurrence (p = 0.003 and 0.043, respectively). One patient (0.3 %) developed angiosarcoma in the irradiated region 120 months after the completion of radiation therapy. The 12-year outcome of breast-conserving therapy using whole-breast and boost irradiation with doses of 45 and 14 Gy, respectively, was favorable.
引用
收藏
页码:595 / 604
页数:10
相关论文
共 20 条
[1]   Age, Breast Cancer Subtype Approximation, and Local Recurrence After Breast-Conserving Therapy [J].
Arvold, Nils D. ;
Taghian, Alphonse G. ;
Niemierko, Andrzej ;
Raad, Rita F. Abi ;
Sreedhara, Meera ;
Nguyen, Paul L. ;
Bellon, Jennifer R. ;
Wong, Julia S. ;
Smith, Barbara L. ;
Harris, Jay R. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (29) :3885-3891
[2]   Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial [J].
Bartelink, Harry ;
Maingon, Philippe ;
Poortmans, Philip ;
Weltens, Caroline ;
Fourquet, Alain ;
Jager, Jos ;
Schinagl, Dominic ;
Oei, Bing ;
Rodenhuis, Carla ;
Horiot, Jean-Claude ;
Struikmans, Henk ;
Van Limbergen, Erik ;
Kirova, Youlia ;
Elkhuizen, Paula ;
Bongartz, Rudolf ;
Miralbell, Raymond ;
Morgan, David ;
Dubois, Jean-Bernard ;
Remouchamps, Vincent ;
Mirimanoff, Rene-Olivier ;
Collette, Sandra ;
Collette, Laurence .
LANCET ONCOLOGY, 2015, 16 (01) :47-56
[3]   Sequencing of chemotherapy and radiation therapy in early-stage breast cancer: Updated results of a prospective randomized trial [J].
Bellon, JR ;
Come, SE ;
Gelman, RS ;
Henderson, IC ;
Shulman, LN ;
Silver, BJ ;
Harris, JR ;
Recht, A .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (09) :1934-1940
[4]   Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials [J].
Darby S. ;
McGale P. ;
Correa C. ;
Taylor C. ;
Arriagada R. ;
Clarke M. ;
Cutter D. ;
Davies C. ;
Ewertz M. ;
Godwin J. ;
Gray R. ;
Pierce L. ;
Whelan T. ;
Wang Y. ;
Peto R. ;
Albain K. ;
Anderson S. ;
Barlow W. ;
Bergh J. ;
Bliss J. ;
Buyse M. ;
Cameron D. ;
Carrasco E. ;
Coates A. ;
Collins R. ;
Costantino J. ;
Cuzick J. ;
Davidson N. ;
Davies K. ;
Delmestri A. ;
Di Leo A. ;
Dowsett M. ;
Elphinstone P. ;
Evans V. ;
Gelber R. ;
Gettins L. ;
Geyer C. ;
Goldhirsch A. ;
Gregory C. ;
Hayes D. ;
Hill C. ;
Ingle J. ;
Jakesz R. ;
James S. ;
Kaufmann M. ;
Kerr A. ;
MacKinnon E. ;
McHugh T. ;
Norton L. ;
Ohashi Y. .
LANCET, 2011, 378 (9804) :1707-1716
[5]  
Goyal S., 2013, PEREZ BRADYS PRINCIP, P1044
[6]   Twenty-year incidence and patterns of contralateral breast cancer after breast conservation treatment with radiation [J].
Hill-Kayser, Christine E. ;
Harris, Eleanor E. R. ;
Hwang, Wei-Ting ;
Solin, Lawrence J. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2006, 66 (05) :1313-1319
[7]   LONG-TERM CLINICAL AND COSMETIC OUTCOMES AFTER BREAST CONSERVATION TREATMENT FOR WOMEN WITH EARLY-STAGE BREAST CARCINOMA ACCORDING TO THE TYPE OF BREAST BOOST [J].
Hill-Kayser, Christine E. ;
Chacko, David ;
Hwang, Wei-Ting ;
Vapiwala, Neha ;
Solin, Lawrence J. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011, 79 (04) :1048-1054
[8]   The Association of Surgical Margins and Local Recurrence in Women with Early-Stage Invasive Breast Cancer Treated with Breast-Conserving Therapy: A Meta-Analysis [J].
Houssami, Nehmat ;
Macaskill, Petra ;
Marinovich, M. Luke ;
Morrow, Monica .
ANNALS OF SURGICAL ONCOLOGY, 2014, 21 (03) :717-730
[9]   Differences in Breast Cancer Stage at Diagnosis and Cancer-Specific Survival by Race and Ethnicity in the United States [J].
Iqbal, Javaid ;
Ginsburg, Ophira ;
Rochon, Paula A. ;
Sun, Ping ;
Narod, Steven A. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 313 (02) :165-173
[10]   Impact of Pathological Characteristics on Local Relapse After Breast-Conserving Therapy: A Subgroup Analysis of the EORTC Boost Versus No Boost Trial [J].
Jones, Heather A. ;
Antonini, Ninja ;
Hart, Augustinus A. M. ;
Peterse, Johannes L. ;
Horiot, Jean-Claude ;
Collin, Francoise ;
Poortmans, Philip M. ;
Oei, S. Bing ;
Collette, Laurence ;
Struikmans, Henk ;
van den Bogaert, Walter F. ;
Fourquet, Alain ;
Jager, Jos J. ;
Schinagl, Dominic A. X. ;
Warlam-Rodenhuis, Carla C. ;
Bartelink, Harry .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (30) :4939-4947