Atovaquone-Proguanil Remains a Potential Stopgap Therapy for Multidrug-Resistant Plasmodium falciparum in Areas along the Thai-Cambodian Border

被引：16

作者：

Saunders, David L. ^{[1
]}

Chaorattanakawee, Suwanna ^{[1
]}

Gosi, Panita ^{[1
]}

Lanteri, Charlotte ^{[1
]}

Somethy, Sok ^{[4
]}

Kuntawunginn, Worachet ^{[1
]}

Ittiverakul, Mali ^{[1
]}

Chann, Soklyda ^{[3
]}

Gregory, Carrie ^{[1
]}

Chuor, Char Meng ^{[2
]}

Prom, Satharath ^{[4
]}

Spring, Michele D. ^{[1
]}

Lon, Chanthap ^{[3
]}

机构：

[1] USAMC AFRIMS, Bangkok, Thailand

[2] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia

[3] USAMC AFRIMS, Phnom Penh, Cambodia

[4] Royal Cambodian Armed Forces, Phnom Penh, Cambodia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 03期

关键词：

CYTOCHROME-B GENE; IN-VITRO; MALARIA; VIVO; ASSAY; CHEMOPROPHYLAXIS; MUTATIONS; BERGHEI;

D O I：

10.1128/AAC.02302-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Our recent report of dihydroartemisinin-piperaquine failure to treat Plasmodium falciparum infections in Cambodia adds new urgency to the search for alternative treatments. Despite dihydroartemisinin-piperaquine failure, and higher piperaquine 50% inhibitory concentrations (IC(50)s) following reanalysis than those previously reported, P. falciparum remained sensitive to atovaquone (ATQ) in vitro. There were no point mutations in the P. falciparum cytochrome b ATQ resistance gene. Mefloquine, artemisinin, chloroquine, and quinine IC(50)s remained comparable to those from other recent reports. Atovaquone-proguanil may be a useful stopgap but remains susceptible to developing resistance when used as blood-stage therapy.

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收藏

页码：1896 / 1898

页数：3

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