Poly(ADP-ribosyl)ation in mammalian ageing

被引：81
作者：
Beneke, Sascha [1 ]
Buerkle, Alexander [1 ]
机构：
[1] Univ Konstanz, Dept Biol, Mol Toxicol Grp, D-78457 Constance, Germany
来源：
NUCLEIC ACIDS RESEARCH | 2007年 / 35卷 / 22期
关键词：
D O I：
10.1093/nar/gkm735
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA damage-induced poly(ADP-ribosyl)ation and mammalian longevity. Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through which poly(ADP-ribosyl) ation might act as a factor that limits the rate of ageing.
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收藏
页码：7456 / 7465
页数：10
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