Therapeutic potential of novel Na+-Ca2+ exchange inhibitors in attenuating ischemia-reperfusion injury

被引：0
作者：
Lee, C [1 ]
Dhalla, NS [1 ]
Hryshko, LV [1 ]
机构：
[1] Univ Manitoba, Fac Med, Dept Physiol, St Boniface Gen Hosp Res Ctr,Inst Cardiovasc Sci, Winnipeg, MB R2H 2A6, Canada
来源：
CANADIAN JOURNAL OF CARDIOLOGY | 2005年 / 21卷 / 06期
关键词：
calcium; ischemia; pharmacology; reperfusion; reperfusion injury; sodium;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The cardiac Na+-Ca2+, exchanger (NCX) plays an essential role in regulating Ca2+ under physiological and pathophysiological conditions. In its forward mode of operation, which predominates under physiological conditions, it extrudes the Ca2+ that enters the cardiac myocyte on a beat-to-beat basis. During ischemia and reperfusion, increased intracellular Na+ leads to a decrease in Ca2+, efflux and enhanced Ca2+ influx Via the NCX, potentially leading to Ca2+ overload, which is one of the major pathophysiological mechanisms for ischemia-reperfusion injury. Novel NCX inhibitors discovered in recent years have shown great promise in attenuating ischemia-reperfusion injury.
引用
收藏
页码：509 / 516
页数：8
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