Magnetic targeting of aerosol particles for cancer therapy

被引：49

作者：

Ally, J

Martin, B

Khamesee, MB

Roa, W

Amirfazli, A ^{[1
]}

机构：

[1] Univ Alberta, Dept Mech Engn, Edmonton, AB T6G 2G8, Canada

[2] Univ Waterloo, Dept Mech Engn, Waterloo, ON N2L 3G1, Canada

[3] Univ Alberta, Dept Oncol, Edmonton, AB T6G 1Z2, Canada

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2005年 / 293卷 / 01期

关键词：

magnetic drug targeting; aerosol drug delivery; magnetic separation; lung cancer; bronchial drug delivery; model for lung therapy; simulation; aerosol distribution; carbonyl iron particles;

D O I：

10.1016/j.jmmm.2005.02.038

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

An in vitro model was developed to study and demonstrate the potential and feasibility of magnetically targeted deposition of aerosols for potential applications in lung cancer treatment. Also, a numerical particle tracing model was developed to predict the targeting behavior of the in vitro system; the results from the numerical and experimental studies were in agreement. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：442 / 449

页数：8

共 9 条

[1]

Dikanskii Y. I., 1998, Magnetohydrodynamics, V34, P212

[2]

Finlay W.H., 2001, The mechanics of inhaled pharmaceutical aerosols: an introduction

[3]

Gerber R. B. R. R., 1983, HIGH GRADIENT MAGNET

[4] Targeting and retention of magnetic targeted carriers (MTCs) enhancing intra-arterial chemotherapy [J].