Therapeutic Experience of Progressive Multifocal Leukoencephalopathy Development during Ofatumumab Therapy for Chronic Lymphocytic Leukemia

被引：2

作者：

Hashimoto, Yu ^{[1
,2
]}

Tashiro, Takumi ^{[1
]}

Ogawa, Ryosuke ^{[3
]}

Nakamichi, Kazuo ^{[4
]}

Saijo, Masayuki ^{[4
]}

Tateishi, Takahisa ^{[1
,5
]}

机构：

[1] Japan Community Hlth Care Org, Dept Neurol, Kyushu Hosp, Kitakyushu, Fukuoka, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Neurol Inst, Dept Neurol, Fukuoka, Japan

[3] Japan Community Hlth Care Org, Dept Hematol, Kyushu Hosp, Kitakyushu, Fukuoka, Japan

[4] Natl Inst Infect Dis, Dept Virol 1, Tokyo, Japan

[5] Kurume Univ, Dept Med, Div Respirol Neurol & Rheumatol, Sch Med, Kurume, Fukuoka, Japan

来源：

INTERNAL MEDICINE | 2021年 / 60卷 / 24期

关键词：

progressive multifocal leukoencephalopathy; ofatumumab; chronic lymphocytic leukemia; NATALIZUMAB; RITUXIMAB; PATIENT;

D O I：

10.2169/internalmedicine.6723-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 79-year-old man experienced cognitive impairment and visual field defects during ofatumumab therapy for chronic lymphocytic leukemia refractory to combination chemotherapy. Magnetic resonance imaging revealed T1-weighted low-intensity and T2-weighted high-intensity lesions with patchy gadolinium enhancement in the subcortical white matter. A diagnosis of progressive multifocal leukoencephalopathy was mad after the detection of John Cunningham virus (JCV) DNA in his cerebrospinal fluid (CSF). Following plasma exchange and the administration of mirtazapine and mefloquine, the JCV DNA levels in the CSF decreased. However, the patient died 55 days after treatment was initiated. Ofatumumab treatment appears to be associated with the development of progressive multifocal leukoencephalopathy.

引用

页码：3991 / 3993

页数：3

共 13 条

[1] PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY - A HITHERTO UNRECOGNIZED COMPLICATION OF CHRONIC LYMPHATIC LEUKAEMIA AND HODGKINS DISEASE [J].

ASTROM, KE ;

MANCALL, EL ;

RICHARDSON, EP .

BRAIN, 1958, 81 (01) :93-&

[2] Classifying PML risk with disease modifying therapies [J].

Berger, Joseph R. .

MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2017, 12 :59-63

[3] Progressive multifocal leukoencephalopathy and other forms of JC virus disease [J].

Brew, Bruce J. ;

Davies, Nicholas W. S. ;

Cinque, Paola ;

Clifford, David B. ;

Nath, Avindra .

NATURE REVIEWS NEUROLOGY, 2010, 6 (12) :667-679

[4] Treatment of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome with intravenous immunoglobulin in a patient with multiple sclerosis treated with fingolimod after discontinuation of natalizumab [J].

Calic, Z. ;

Cappelen-Smith, C. ;

Hodgkinson, S. J. ;

McDougall, A. ;

Cuganesan, R. ;

Brew, B. J. .

JOURNAL OF CLINICAL NEUROSCIENCE, 2015, 22 (03) :598-600

[5] Monoclonal anti body-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project [J].

Carson, Kenneth R. ;

Focosi, Daniele ;

Major, Eugene O. ;

Petrini, Mario ;

Richey, Elizabeth A. ;

West, Dennis P. ;

Bennett, Charles L. .

LANCET ONCOLOGY, 2009, 10 (08) :816-824

[6] Disease course and outcome of 15 monocentrically treated natalizumab-associated progressive multifocal leukoencephalopathy patients [J].

Dahlhaus, Stefanie ;

Hoepner, Robert ;

Chan, Andrew ;

Kleiter, Ingo ;

Adams, Ortwin ;

Lukas, Carsten ;

Hellwig, Kerstin ;

Gold, Ralf .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2013, 84 (10) :1068-1074

[7] Rapid cognitive decline in a patient with chronic lymphocytic leukaemia: a case report [J].

Forryan, James ;

Yong, Jun .

JOURNAL OF MEDICAL CASE REPORTS, 2020, 14 (01)

[8] Ofatumumab versus Teriflunomide in Multiple Sclerosis [J].

Hauser, Stephen L. ;

Bar-Or, Amit ;

Cohen, Jeffrey A. ;

Comi, Giancarlo ;

Correale, Jorge ;

Coyle, Patricia K. ;

Cross, Anne H. ;

de Seze, Jerome ;

Leppert, David ;

Montalban, Xavier ;

Selmaj, Krzysztof ;

Wiendl, Heinz ;

Kerloeguen, Cecile ;

Willi, Roman ;

Li, Bingbing ;

Kakarieka, Algirdas ;

Tomic, Davorka ;

Goodyear, Alexandra ;

Pingili, Ratnakar ;

Haring, Dieter A. ;

Ramanathan, Krishnan ;

Merschhemke, Martin ;

Kappos, Ludwig .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (06) :546-557

[9] No evidence of beneficial effects of plasmapheresis in natalizumab-associated PML [J].

Landi, Doriana ;

De Rossi, Nicola ;

Zagaglia, Sara ;

Scarpazza, Cristina ;

Prosperini, Luca ;

Albanese, Maria ;

Buttari, Fabio ;

Mori, Francesco ;

Marfia, Girolama Alessandra ;

Sormani, Maria Pia ;

Capra, Ruggero ;

Centonze, Diego .

NEUROLOGY, 2017, 88 (12) :1144-1152

[10] Progressive Multifocal Leukoencephalopathy after Ibrutinib Therapy for Chronic Lymphocytic Leukemia [J].

Lutz, Mathias ;

Schulze, Arik B. ;

Rebber, Elisabeth ;

Wiebe, Stefanie ;

Zoubi, Tarek ;

Grauer, Oliver M. ;

Kessler, Torsten ;

Kerkhoff, Andrea ;

Lenz, Georg ;

Berdel, Wolfgang E. .

CANCER RESEARCH AND TREATMENT, 2017, 49 (02) :548-552

← 1 2 →